Prostate Specific Antigen Level in Exposure to Sulfur Mustard
Journal Title: Iranian Journal of Blood and Cancer - Year 2017, Vol 9, Issue 4
Abstract
Background: Oxidants and inflammation agents are predisposing factors for the development of prostate cancer. As a chemical warfare, sulfur mustard (SM) can cause cancer through various pathways mainly increased production of oxidants and inflammation. Due to high incidence of cancer in SM victims, concentration of prostate specific antigen (PSA) in SM victims was evaluated and compared with the control group. Methods: This study was conducted on 150 subjects exposed to SM as the Iranian chemical victim group and 150 non-exposed healthy subjects matched for age and sex, as the control group. The serum concentration of PSA was measured by Enzyme-linked Immunosorbent assay. Results: According to spirometry results, the SM exposure rate in the chemical victim group was mild, moderate, and severe in 66%, 27% and 7%, respectively. The mean time elapsed from exposure to SM in case group was 30 years. 100% of the victims had consumed N-acetylcysteine for alleviating symptoms due to exposure to SM. Decreased concentration of PSA in SM victims compared with control group was observed; even non-significant. (0.728 vs 0.844 ng/ml, P=0.103). Conclusion: PSA concentrations were expected to increase in SM victims, but in our study an opposite result was observed. It is assumed that consumption of N-acetylcysteine with known anti-inflammatory features, mild exposure and shorter period of time elapsed from exposure to SM may be the reasons for this results. Further studies on these subjects seem to be necessary to prove the efficacy of antioxidants such as N-acetylcysteine in prevention of prostate cancer in subjects who have the history of SM exposure.
Authors and Affiliations
Yunes Panahi, Mohammad Yousef Alikhani, Mohammad Rafiee, Alireza Saadat, Hassan Rafieemehr
Keywords
Related Articles
- EP ID EP281307
- DOI -
- Views 100
- Downloads 0
Therapeutic Plasma Exchange in Pediatric Severe Immune Thrombocytopenia: A Case Report and Literature Review
Treatment of severe Immune Thrombocytopenic purpura (ITP) accompanied by life-threatening bleeding events is challenging and a combination of treatment measures should be undertaken to rapidly increase the platelet count...
Frequency of Torque Teno Mini Virus in Hepatitis B and C Patients and Healthy Blood Donors in Isfahan, Iran
Background: Recently, some new viruses have been identified for their association with hepatitis which Torque Teno Mini Virus being among them. The aim of this study was to determine the frequency of Torque Teno Mini Vir...
A Case of Acute Myeloid Leukemia Caused by Low Dose Methotrexate Used to Treat a Rheumatoid Arthritis Patient
Methotrexate is an anti-rheumatic agent used as a first-line tretment for rheumatoid arthritis. Hematological malignancies like lymphoma or acute myeloid leukemia have been reported to be secondary to treatment with Meth...
Metronomic Effect as A New Hypothesis in Maintenance Therapy of Acute Lymphoblastic Leukemia
This article has no abstract.
Unusual Presentation of T-cell non-Hodgkin Lymphoma with Multiple Skin Nodules
Non-Hodgkin lymphoma is very uncommon in infancy and skin as the primary site of involvement in Non-Hodgkin lymphoma is rarely encountered. We describe a 10-month-old infant with T-cell Non-Hodgkin lymphoma who presented...