Protective Effect of Agaricus bisporus (Button mushroom) on Cisplatin Induced Nephrotoxicity in Albino Rats
Journal Title: World Journal of Pharmaceutical Sciences - Year 2016, Vol 4, Issue 9
Abstract
The present study was carried out to investigate the nephroprotective effect of Agaricus bisporus extract on nephrotoxicity induced by cisplatin in male albino rats .Rats were randomly divided in to four groups. Group I was treated as normal control. Group II was treated with single intraperitonial dose of cisplatin (16mg/kg body weight) on 1st day. Group III was treated with single intraperitonial dose of cisplatin on 1st day which is followed by the oral dose of silymarin (50mg/kg body weight/day) from 2nd day to 15thday. Group IV was treated with single intraperitonial dose of cisplatin on 1st day which is followed by the oral dose of Agaricus bisporus (200mg/kg body weight/day) from 2nd day to 15thday. Biochemical results of Agaricus bisporus treated group showed a decreased in levels of blood urea, uric acid, blood urea nitrogen and creatinine and increased in body weight, albumin and total protein when compared to cisplatin treated groups. Hematological results of Agaricus bisporus treated group also showed an increased in levels of Hb, RBC, WBC, PCV, MCV and MCHC when compared to cisplatin treated rats. The results of this study were concluded that Agaricus bisporus protected the rats from the deleterious effect of cisplatin.
Authors and Affiliations
Rajasekar R
Keywords
Related Articles
- EP ID EP202270
- DOI -
- Views 105
- Downloads 0
Quantitative structure activity relationship: A tool for new drug design
The concept of Quantitative structure activity relationship has typically been used for drug discovery and development. It has gained wide applicability for correlating molecular information with biological activities in...
A study on association of fibrinogen and oxidative stress in prognosis of diabetic foot ulcer in tertiary government hospital
Diabetes mellitus is the most common metabolic disorder characterized by metabolic abnormalities and long term complications. Diabetic foot ulcer has poor prognosis and is a leading cause of amputation. Oxidative stress...
Personality factors and Coping Skills among Coronary Heart Disease Patients
Coronary heart disease is a leading cause of death and a cause of disability worldwide. Personality factors and coping skills are important determinants of morbidity and mortality associated with Coronary artery disease....
Polyphenols of tea as powerhouse for healthcare because TEA is Tremendous Effective Antioxidant
Tea contains antioxidants. Tea has less caffeine than coffee. Coffee usually has two to three times the caffeine of tea. An eight-ounce cup of coffee contains around 135 mg caffeine; tea contains only 30-40 mg per cup. T...
Synthesis, characterization and identification of sertraline hydrochloride related impurities
Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class, is synthesized for commercial use as a drug substance in highly pure form. During commercial production of Sertral...