PROTECTIVE EFFECT OF CAFFEIC ACID PHENETHYL ESTER AGAINST MYOPATHY INDUCED BY ATORVASTIN AND ROSUVASTATIN
Journal Title: Kocatepe Medical Journal - Year 2023, Vol 24, Issue 3
Abstract
OBJECTIVE: Due to the fact that statins cause myopathy in some patients, the patient's compliance with the treatment decreases, and the treatment is interrupted or drug is changed. In this study, oxidative stress and inflammation, two conditions in which statins can cause myopathy, were studied and the protective role of Caffeic acid phenethyl ester (CAPE) was tested experimentally. MATERIAL AND METHODS: Rhabdomyosarcoma (RD) cell lines were used in the study. Cells were divided into 6 groups as control, atorvastatin, rosuvastatin, CAPE, atorvastatin+CAPE and rosuvastatin+CAPE. Total Antioxidant Capacity (TAC), Total Oxidative Capacity (TOC), and Oxidative Stress Index (OSI) analyzes were made spectrophotometrically; Interleukin 6 (IL-6) levels were demonstrated both at the protein level by ELISA and at the level of mRNA expression by real time PCR. RESULTS: OSI, which was 1739 in the control group, increased to 3814 with atorvastatin application and decreased to 2109 with the combination of atorvastatin and CAPE. There was no change in OSI levels in Rosuvastatin and Rosuvastatin and CAPE combination compared to the control group. While IL-6 mRNA expression levels were found to be similar to the control group in the atorvastin group, an increase of 2.369 times was observed in the Rosuvastatin group compared to the control group. As a result of the combination of rosuvastatin with CAPE, it was determined that IL-6 mRNA expression levels were reduced to the level of the control group. CONCLUSIONS: In this study, it was observed that atorvastatin triggered oxidative stress in RD cell lines, while rosuvastatin increased the expression level of IL-6 mRNA and paved the way for the process leading to proinflammation. The combination of CAPE was found to be functional in suppressing oxidative stress caused by atorvastatin and inflammation caused by rosuvastatin. In this regard, it has been shown that the combination of atorvastatin and rosuvastatin with CAPE may have positive results for the benefit of the patient on muscle damage caused by statins.
Authors and Affiliations
Serkan ŞEN Canan YILMAZ
Keywords
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- EP ID EP722668
- DOI https://doi.org/10.18229/kocatepetip.1166270
- Views 43
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