PROTECTIVE EFFECT OF L-CARNITINE AND BAKER YEAST SACCHAROMYCES CEREVISIAE AGAINST HEPATIC TOXICITY INDUCED BY VALPROATE AS ANTIEPILEPTIC DRUG IN RATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 5
Abstract
Objective: The aim of this work was to investigate the protective role of L-carnitine and baker yeast (Saccharomyces cerevisiae) against the effect of sodium valproate (VPA) induced toxicity and oxidative stress in the liver.Methods: Chronic administration of sodium valproate was studied by oral administration of VPA for six months. The protective effect was conducted by an administration of L-carnitine or/and baker yeast for one month before chronic administration of VPA. Some biochemical parameters, lipid profile, oxidative stress and histopathological studies were analyzed.Results: Chronic administration of VPA for six months caused a significant increase in serum amino transferases (AST, ALT), alkaline phosphatase (ALP), bilirubin, total lipids, total cholesterol, low density lipoprotein (LDL) as well as oxidative stress; malodialdehyde (MDA) and nitric oxide. While decreased total protein, albumin, and globulin in addition to glutathione peroxidase and superoxide dismutase (SOD). The administration of L-carnitine and baker yeast cause significant decreases in the activities of AST, ALT, bilirubin, lipid peroxidation, LDL level and MDA levels and return the levels of total protein, albumin, globulin, glutathione peroxidase and SOD to the normal levels. Histopathological results revealed improvement of the liver structure.Conclusion: L-carnitine and baker yeast (Saccharomyces cerevisiae) offer protection to the liver by preserving the structural integrity of hepatocellular membrane against sodium valproate induced hepatotoxicity and oxidative stress.Â
Authors and Affiliations
Shebl Shaalan, Amany S. E El-wakkad, Hanan Saleh
Keywords
Related Articles
- EP ID EP578785
- DOI -
- Views 75
- Downloads 0
PHARMACOEPIDEMIOLOGICAL SURVEY ON THE USE OF COSTUS PICTUS (INSULIN PLANT) IN CENTRAL KERALA
Objective: Costus pictus commonly known as spiral ginger or insulin plant is grown in gardens as ornamental plant especially in Kerala and used to control sugar levels. The objective of the present survey was to collect...
WOUND HEALING POTENTIAL OF YOUNG LEAVES OF TRITICUM AESTIVUM ON ALLOXAN INDUCED DIABETIC RATS
Objective: Wheatgrass is known to have several medicinal properties to treat various disorders. Triticum aestivum Linn. is a traditional medicinal plant apparently used for bowel disorders, skin inflammation, infection,...
BIOACTIVE FRACTION DLBS2411 FROM CINNAMOMUM BURMANNII, (NEES AND T. NEES) BLUME AS COLON AND GASTROPROTECTOR BY STIMULATING MUC5AC AND CYCLOOXYGENASE-2 GENE EXPRESSION
Objective: Mucus therapy is one of the therapies for gastric ulcer management aside from proton pump inhibitor (PPI) and H2-blocker medication. Bioactive fraction DLBS2411 which comes from Cinnamomum burmannii has been i...
BROWN SEAWEEDS AMELIORATE RENAL ALTERATIONS IN MICE TREATED WITH THE CARCINOGEN AZOXYMETHANE
Objectives: The current study was conducted to evaluate the possible protective effects of the brown seaweeds, Turbinaria ornata and Padina pavonia, against azoxymethane (AOM)-induced nephrotoxicity in mice.Methods: The...
SYNERGISTIC EFFECT OF CURCUMA LONGA AND GLYCYRRHIZA GLABRA EXTRACTS WITH COPPER IONS ON FOOD SPOILAGE BACTERIA
Objective: To evaluate the synergistic antibacterial activity of ethanolic and aqueous extracts of Curcuma longa and Glycyrrhiza glabra in combination with copper metal ions. Methods: The phytochemical analysis of Curcum...