PROTECTIVE EFFECT OF ROTENONE AGAINST LIPOPOLYSACCHARIDE AND D-GALACTOSAMINE-INDUCED HEMATOTOXICITY
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 8
Abstract
Objective: The aim of the present study was to investigate the protective efficacy of rotenone against lipopolysaccharide (LPS) and D-galactosamine (D-GalN)-induced altered hematology. Methods: Hematotoxicity was induced by coinjection of LPS (50 μg/kg i.p.) and D-GalN (300 mg/kg i.p.). Rotenone (5, 10 and 20 mg/kg p.o.) was administered for 6 days as a pre-treatment. Blood was collected through puncturing the retro-orbital sinus to analyze blood parameter. Serum was separated to analyze glucose, triglyceride, and cholesterol. Results: The present study revealed decreased in red blood cells, platelets, hemoglobin, and hematocrit value while a significant increase in white blood cells, lymphocyte, and monocytes were observed in LPS and D-GalN treated rats. LPS and D-GalN administration significantly decrease glucose level while serum lipid profile (triglycerides and cholesterol level) were increased significantly at 5% level of significance. LPS and D-GalN-induced altered hematological and serological variables were restored toward control by rotenone pretreatment for 6 days in dose-dependent manner. Conclusion: It can be said that LPS and D-GalN administration resulted in alteration of various hematological parameters and rotenone at 20 mg/kg dose restored significant alteration toward control due to the presence of antioxidant activity of rotenone.
Authors and Affiliations
SAMRAT RAKSHIT , ANJANI VERMA , SATENDRA KUMAR NIRALA , MONIKA BHADAURIA
Keywords
Related Articles
- EP ID EP636153
- DOI -
- Views 119
- Downloads 0
SPECTROSCOPIC CHARACTERIZATION OF PHYTOCONSTITUENTS ISOLATED FROM A RARE MANGROVE AEGIALITIS ROTUNDIFOLIA ROXB., LEAVES AND EVALUATION OF ANTIMICROBIAL ACTIVITY OF THE CRUDE EXTRACT
Objective: The aim of the study is to isolate and characterize the phytochemicals from the leaves of a rare and unexplored mangrove Aegialitis rotundifolia and evaluate the antimicrobial properties of the crude extract....
IN VITRO CYTOTOXIC ACTIVITY OF RODENT TUBER MUTANT PLANT (TYPHONIUM FLAGELLIFORME LODD.) AGAINST TO MCF-7 BREAST CANCER CELL LINE
Objective: The objective of this study was to determine the new bioactive compounds through gas chromatography–mass spectrometry analysis and the cytotoxic activity of two rodent tuber mutant plants against breast cancer...
FUSOGENIC LIPOSOME FOR THE TREATMENT OF FUNGAL MENINGITIS: AN OVERVIEW
Fungal meningitis is an infection which is caused by fungus which spreads through the blood to the spinal cord. People with weakened immunity get this disease easily like persons with AIDs, etc. To make sure the disease...
A STUDY ON THE EFFECT OF DIETARY FACTORS ON FUNCTIONAL GASTROINTESTINAL DISORDERS IN WOMEN OF HA’IL REGION IN SAUDI ARABIA
Objective: The aim of this study is to assess the prevalence of functional gastrointestinal disorders (FGIDs) among the women population of the Ha’il region in Saudi Arabia. It also includes the analysis of the effect...
A SUBCHRONIC TOXICITY TEST OF ETHANOL EXTRACT FROM TUNJUK LANGIT RHIZOME (HELMINTHOSTACHYS ZEYLANICA) ON ALBINO RATS, RATTUS NOVERTICUS (WISTAR STRAIN)
Objective: Traditionally, Tunjuk langit (Helmynthostachis zaylanica) rhizome has been used as anticancer and anti-inflammation drugs; however, it may have toxic effects on major organs for a long-term continuously consec...