Protective effects of aqueous extract of internal septum of walnut fruit on diabetic hepatopathy in streptozotocin-induced diabetic mice
Journal Title: مجله علمي دانشگاه علوم پزشكي كردستان - Year 2018, Vol 23, Issue 93
Abstract
Backgrounds and Aim: Treatment of diabetes by ethnomedicinal plants which have fewer side effects than chemical drugs has been on the rise. In this study we assessed hepatoprotective and antidiabetic effects of aqueous extract of internal septum of walnut fruit (ISWF) on diabetic mice. Material and Methods: In this experimental study 35 mature male mice were made diabetic by administration of 60 mg/kg of streptozotocin intraperitoneally. The mice were randomly divided into 5 groups. The negative (non diabetic) and positive (diabetic) control groups received normal saline and the 1st, 2nd and 3rd treatment groups received 0.5 mg/kg of glibenclamide, 200 and 400 μl/kg of aqueous extract of ISWF through gavage respectively for 15 days. On the last day, serum levels of blood glucose, ALT (alanine aminotransferase), AST (aspartate aminotransferase) and ALP (alkaline-phosphatase) were measured. After tissue processing, we measured total volume of the liver, hepatocytes, sinusoids, portal vein, central vein, hepatic arteries and bile ducts in the sections of the tissues. Results: Use of aqueous extract of ISWF in the treatment groups led to significant decrease in blood glucose levels, AST and ALP enzymes and also total volume of liver, sinusoids and central vein (p<0.05) compared to those in the non-treated diabetic group. Conclusion: According to the results, aqueous extract of ISWF, can regulate the blood glucose level and inhibit hepatic damage in streptozotocin-induced diabetic mice.
Authors and Affiliations
A Zangeneh, MM Zangeneh, DVSc N Goodarzi, PhD F Najafi, PhD L Hagh Nazari
Keywords
Related Articles
- EP ID EP283366
- DOI -
- Views 59
- Downloads 0
Anti-cancer effect of phosphatidylinositol 3-kinase inhibitor on NB4 leukemic cells
Background and Aim: In the last decades, experimental studies have shown that aberrant activation of phosphatidylinositol 3-kinase (PI3K) pathway is an essential step for both initiation and maintenance of tumorgenesis i...
Evaluation of inhibitory effect of caffeine on bone morphogenesis in pregnancy in a model of rat embryos
Background and Aim: High intake of caffeine and its side effects have attracted attention. Caffeine used by pregnant and breast-feeding women can enter the baby's body through placenta and milk. There have been many stu...
A pattern for conceptual extent and measurement of nurses social undermining
Background and Aim: In recent years, researchers in the field of behavioral sciences have pointed to one of the complications and dark points of the organizational communication system which is called social undermining....
Explaining risky and unprotected sexual behaviors among young people and related reasons: A qualitative study
Background and Aim: Risky and unprotected sexual behaviors are among the health threatening factors which can increase the risk of transmission of HIV/AIDS and hepatitis especially in young people. This qualitative study...
Epidemiological study of irritable bowel syndrome and its related factors in Sanandaj from 2013 to 2014: a population-based study
Background and Aim: Irritable bowel syndrome is a common gastrointestinal disease which is characterized by abdominal pain and altered bowel habits. This study aimed to investigate the prevalence of irritable bowel syndr...