Protective effects of hydro-alcoholic garlic extract on spermatogenic disorders in streptozotocin-induced diabetic C57BL/6 mice
Journal Title: مجله علمي دانشگاه علوم پزشكي كردستان - Year 2017, Vol 22, Issue 90
Abstract
Background and Aim: Diabetes can cause sexual dysfunction including spermatogenic disorders in the diabetic patients. The aim of the present study was to investigate the antioxidant effects of garlic extract in diabetic mice. Materials and Methods: Diabetes was induced by multiple low-dose streptozotocin injections (40 mg/kg/day for 5 consecutive days), in male C57BL/6 mice (15-20 gr body weight). After induction of diabetes, the mice were divided into 4 groups: group 1 (normal control group); group 2 (diabetic control group); group 3 (treatment with garlic extract 200 mg/kg for 35 days) and group 4 (treatment with garlic extract 400 mg/kg for 35 days). Mice were euthanized on the 35th day and serum testosterone levels were estimated. Testes and epididymis were removed for sperm evaluation and measurement of nitric oxide (NO) levels and total antioxidant capacity (TAC). Results: Garlic treatment significantly improved semen parameters and increased serum level of testosterone (p<0.05). Aside from reducing the elevated tissue nitric oxide level, garlic increased total antioxidant capacity in testis tissue samples. Conclusion: This study showed potent antioxidant effect of hydro-alcoholic garlic extract on the testes of mice against type 1 diabetes -induced oxidative stress.
Authors and Affiliations
PhD A Soleimanzadeh, MSc F Malekifard, MSc A. R Kabirian
Keywords
Related Articles
- EP ID EP282922
- DOI -
- Views 93
- Downloads 0
Effect of prenatal immobilization stress on spatial memory, anxiety-like behavior and brain BDNF concentration in the F1 generation male mice
Background and Aim: In this study, we investigated the effect of immobilization stress during pregnancy on the spatial memory, anxiety-like behavior and brain BDNF level in F1 generation male NMRI mice. Materials and Met...
Views of managers, health care providers, and clients about problems in implementation of urban family physician program in Iran: A qualitative study
Background and Aim: From 2011 to 2013 some efforts had been made in Iran to implement urban family physician program. The aim of this study was to determine the viewpoints of managers, providers, and clients of health ca...
Barriers to the treatment of insomnia from patients' perspectives: a qualitative study
Background and Aim: Insomnia is a common problem in general population. It is associated with negative consequences on daily living. Insomnia is an under recognized disease, and patients may seek treatment very late, whi...
Effect of “Roy adaptation model” in physiologic aspect on the level of consciousness of patients in intensive care unit: A clinical trial
Background and Aim: One of the indicators of recovery in the patients admitted to intensive care units is improvement of the level of consciousness. Various factors, including the type of care are effective in the change...
Assessment of protective effect of ethyl pyruvate on sperm parameters, and trend of embryological development after in vitro fertilization (IVF) in phenylhydrazine treated mice
Background and Aim: Oxidative stress can lead to change in the sperm parameters and cessation of embryological development This study aimed to assess the protective effect of ethylpyruvate (EP) on sperm parameters and tr...