Protective Effects of the Combination of the Herbal Compound Against Inflammation Related to Obesity and Colitis Induced by Diet in Mice
Journal Title: Iranian journal of diabetes and obesity (IJDO) - Year 2022, Vol 14, Issue 1
Abstract
Objective: High-fat diet (HFD) rises the susceptibility of both obesity and consequently Inflammatory Bowel Disease (IBD). We designed a study to investigate the improving effects of herbal extract (HE, the combination of turmeric, ginger, boswellia, and cat’s claw extract) on the risk of high AGEs-fat diet 60% (HFD) mice induced colitis and obesity. Materials and Methods: Four-week-old C57BL/6 male mice after 2 weeks adaptation with normal diet were fed with either HFD or normal diets. After 6 weeks of being on diet, animals received HE for 16 weeks. Obesity index markers were determined as well as histological studies using H&E (Hematoxylin-eosin) staining. Colonic expression of IL-1β was determined. Data analysis was performed by utilizing Kruskal-Wallis and Mann-Whitney test for post-hoc comparisons, and SPSS (version 17.0) and GraphPad Prism Software (Version 8.0, USA). Results: HE decreased histological scores (by 6-fold) in HFD diet-fed mice, and reduced myeloperoxidase activity (by 2.2-fold), and ratio of colon weight to length (by 4-fold) in HFD diet-fed mice. Moreover, HE prevented intestinal permeability through the restoration of ZO-1 (by 4-fold) and immune homeostasis by modulation of IL-1β (by 2.4-fold) expression. Conclusion: HFD induced obesity-associated colitis. HE decreased the colitis symptoms in HFD diet-fed mice, with the reduction of inflammation.
Authors and Affiliations
Fatemeh Azizian-Farsani,Navid Abedpoor,Maryam Derakhshan,Mohammad Hossein Nasr-Esfahani,Mohammad Hasan Sheikhha,Kamran Ghaedi,
Keywords
Related Articles
- EP ID EP700562
- DOI 10.18502/ijdo.v14i1.8740
- Views 59
- Downloads 0
Correlation between Cytochrome P450, 5-alpha Reductase, and Androgen Receptor Levels in Patients with Type 2 Diabetes Mellitus
Objective: Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases. The CYP450 plays an important role in the biosynthesis of steroid hormones and the hormonal activity is mediated by the androgen rece...
Over Expression of FOXO1 in Subcutaneous Fatty Tissue and its Response to Resistance Training in High Fat Diet and Type 2 Diabetic Rat
Objective: Forkhead box proteins and Forkhead box transcription factor O1 (FOXO1) in particular, mediate insulin signaling pathways and glucose homeostasis. This study aimed to compare FOXO1 expression in subcutaneous ad...
Prevalence of Complications of Diabetes and Risk Factors Among Patients with Diabetes in the Diabetes Clinic in Southeast of Iran
Objective: Academic health services play an important role in the prevention and control of diabetes mellitus (DM) in Iran. This study aimed at determining the prevalence of DM-related complications and the associated ri...
How is the Effect of Physical Activity on Non-Alcoholic Fatty Liver in Obese People? A Mini Review
Nonalcoholic fatty liver is known in the general public as an epidemic disease. The purpose of this mini-review was to determine a link between physical education (PA) and the risk of nonalcoholic fatty liver disease (NA...
Evaluation of the of Positive Psychology Training Effectiveness on Rumination and Depression in Women with Type 2 Diabetes
Objective: Preventing chronic diseases is important for public health. The aim of this study was evaluation the effectiveness of positive psychology (PP) training on rumination and depression in women with type 2 diabete...