PROVISION OF LOW-DOSE PROPRANOLOL IN PATIENTS WITH ACUTE ISCHEMIC STROKE AGAINST THE LEVELS OF TNF-Α, IL-10, AND THE RATIO OF TNF-Α / IL-10 AT “ABDUL MOELOEK” GENERAL HOSPITAL, BANDAR LAMPUNG, INDONESIA
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2018, Vol 4, Issue 1
Abstract
Brain and the immune system are linked through sympathetic, parasympathetic nervous system and HPA axis. Relationship between brain and immune system is thought to be through molecules secreted by the necrotic brain tissues. Immune system alterations in ischemic stroke can be seen with the presence of lymphopenia, immediate increment and followed by decrement of proinflammatory cytokines (TNF-α) and elevated anti-inflammatory cytokines (IL-10). According to animal study, this condition can be controlled by giving propranolol. The aim of this study was to demonstrate the effect of 2x10 mg propranolol on TNF-α, IL-10, and TNF-α/IL-10 ratio in acute ischemic stroke patients with lymphopenia. This is an experimental research with pretest-postest match control group study design. Samples used in this study were 40 ischemic stroke patients with lymphopenia. The study was conducted in “Abdul Moeloek” General Hospital, Bandar Lampung, Indonesia from July, 2016 to February, 2017. Patients were divided into 2 groups; ischemic stroke group without propranolol, and ischemic stroke group with propranolol. TNF-α and IL-10 levels were examined by ELISA. The results showed that reduction of in TNF-α levels in the group treated with propranolol was lower (p=0.221). IL-10 levels increased in the group without propranolol (p=0.547). TNF-α/IL-10 ratio in the group with propranolol was higher (p=0.053). Ischemic stroke affects the patient's immune system that show in alteration of TNF-α,IL-10 levels and ratio of TNFα/IL-10. Provision of propranolol 2x10 mg increase TNF-α level, decrease IL-10 level and inrease ratio TNFα/IL-10, but not significant statistically.
Authors and Affiliations
Endang Nurcahyani
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