PSA as a Marker in Breast Cancer: A Clinico-Biochemical Analysis
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 1
Abstract
Breast Cancer is one of the earliest detected neoplasm’s in human beings. Present study comprises all those patients of cancer breast of all stages who attended the outdoor department and admitted in indoor wards of department of Biochemistry and Surgery of Hospital (Swami Vivekanand Subharti University) attached to Subharti Medical College, Meerut. All these patients were clinically evaluated completely by history, clinical examination and various invasive and noninvasive investigations to establish the diagnosis and find out the extent of disease in the body. 4.69% & 45.31% of the breast cancer patients were pre- & postmenopausal respectively. Maximum patients were found to be in stage III (37.5% & 26.56% of pre- & postmenopausal, respectively). 30.8% of premenopausal patients had an ER receptor positive tumour. The percentage of such patients in postmenopausal group was 61.1%. Most of the tumours in postmenopausal females were ER positive. 28.13% of premenopausal and 21.88% of postmenopausal patients had >3 lymph nodes affected. Peripheral PSA levels were observed at the time of diagnosis, in relation to stage, lymph node status, menopausal status, ER/PR status and flow cytometry. After treatment the PSA level were not different from pretreatment levels. During follow up the peripheral PSA levels showed no correlation with recurrence. Keywords: Premenopausal, Postmenopausal, Prostate-specific antigen, Estrogen receptor.
Authors and Affiliations
Dr. Bindu Sharma, Dr. Haren Baruah, Dr. Amit Kumar, Dr. Abhishek Jain
Keywords
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