PSEUDOMONAS AERUGINOSA SKIN-NASOPHARYNGEAL COLONIZATION IN THE IN-PATIENTS: PREVALENCE, RISK FACTORS AND ANTIBIOTIC RESISTANCE IN TERTIARY HOSPITALS IN SANA'A CITY -YEMEN
Journal Title: Universal Journal of Pharmaceutical Research - Year 2018, Vol 3, Issue 6
Abstract
Pseudomonas aeruginosa is one of most important cause of healthcare-associated infections. This active surveillance cross sectional study was aimed to determine the rate of P. aeruginosa colonization among inpatients at three tertiary hospitals in Sana'a city. In addition, to determine risk factors of colonization and the antibiotic susceptibility of the isolated P. aeruginosa. The study included 327 inpatients. Skin and nasopharyngeal swabs were collected from all participated patients and data were collected by predesigned questionnaire. Standard methods of isolation and identification were used to isolate bacteria in pure culture then identify. Also, antibiotic sensitivity for isolated P. aeruginosa was determined by the disc diffusion method. 42 patients (12.8%) were colonized with P. aeruginosa on skin and nasopharyngeal. The significant risk factors of colonization were male patients (OR=2.5), older age (OR= 2.2), burn ward (OR=37), long stay in hospital (OR=4) and burn as underlying disease (OR=45). The isolated P. aeruginosa were completely resistant (100%), to Aztroneome, Ceftriaxone, and Ciprofloxacine; and the rates of resistant were ranged between 83.3-85.7% for Amikacin, Ampicillin sulbactam Levofloxacin. Also the rates were 71.4% for Netilmicin and 92.9% for chloramphenicol. Moreover, the rates of resistant were low for Gentamicin (35.7%), Imipenem (11.9%), Pipracillin Tazobactam (11.9%), Ticaracillin calvulanic acid (31%) and Colistin sulphat (14.3%). In conclusion, this study has highlighted the role of hospitalization as a significant risk for P. aeruginosa colonization; concerted and coordinated efforts are required both in the hospital and community to tackle this. These data emphasize the need to identify hospitalized patients colonized with P. aeruginosa on admission. Prediction rules or rapid diagnostic testing will help clinicians more appropriately choose empiric antibiotic therapy if subsequent infections occurred.
Authors and Affiliations
Rahma Taher Farea AL-Magrami, Hassan Abdulwahab Al-Shamahy
Keywords
Related Articles
- EP ID EP36500
- DOI https://doi.org/10.22270/ujpr.v3i6.219
- Views 298
- Downloads 0
Editorial Message
It is a great honor for me to join the Universal Journal of Pharmaceutical Research (UJPR) as a member in the Editorial Board team. I would like to extremely congratulate all the UJPR team for completing approx. two succ...
THE IMPACT OF STRATEGIC FACTORS OF WASTE MANAGEMENT ON ENVIRONMENTAL PROTECTION IN KAZEROON CITY IN 2017
Today, environment protection is one of main pillars of observing human right, so that protection and maintenance of environment is one of main duties of present and future. After investigating and identifying environmen...
DEVELOPMENT AND EVALUATION OF FAST DISSOLVING THIN FILMS OF ARIPIPRAZOLE
In the current pharmaceutical research fast dissolving films are playing an important role. In the present research, five different rapidly dissolving films of Aripiprazole were prepared successfully by using different p...
WOUND DRESSINGS UPLOADED WITH MYRTLE BERRIES EXTRACT AND NIGELLA SATIVA HONEY
Wound dressings are frequently developed by introducing new products to target different aspects of the wound healing process. Many medicated dressings incorporated with natural extracts and chemicals have been developed...
AWARENESS AMONGST YOUTH ABOUT USE AND ABUSE OF STEROIDS IN KARACHI, PAKISTAN
Aim of present study was to analyze awareness regarding the use of steroids in the youth studying health sciences. A descriptive, observational study was conducted from September to December 2017. Youth studying health...