Psychiatric manifestations of autoimmune diseases – diagnostic and therapeutic problems
Journal Title: Psychiatria Polska - Year 2012, Vol 46, Issue 6
Abstract
In autoimmune diseases, also called connective tissue diseases, many systems and organs are involved, including the central, peripheral and autonomic nervous system. The frequency of neurological and neuropsychiatric manifestations varies in certain autoimmune diseases. One of the most common causes of these symptoms are vascular pathologies, including inflammatory and thrombotic, immunologic and atherosclerotic changes. Neuropsychiatric complications may present as a single symptom or might form a syndrome. In a particular patient, a syndrome might change its form in time, presenting itself as a different syndrome. Quite a lot of these symptoms are not a result of a disease itself but its treatment, metabolic abnormalities, arterial hypertension or infection. Steroids play a particular role in the induction of these complications.The role of increasingly used biological agents is uncertain. The most frequent psychiatric manifestations of the connective tissue diseases are: benign behavioural changes, emotional instability and sleep impairment. Neuropsychiatric symptoms are most frequently seen in systemic lupus erythematosus (up to 80% of these patients), particularly with the co-existent antiphospholipidsyndrome. Psychoses with or without seizures are included in the diagnostic criteria of the disease. A separate clinical problem is an induction of a synthesis of autoantiobodies by some drugs, including psychiatric drugs. These antibodies induce clinical symptoms of an autoimmune disease only in some patients, most frequently the symptoms of lupus erythematous, co called: drug induced lupus, including arthralgia, myalgia, fever, skin lesions and serositis. The diagnosis and treatment of psychiatric complications of autoimmune diseases is quite complicated. It is extremely important to distinguish whether a particular symptom is primary to the disease itself or secondary to its treatment. The most important recommendations are treatment of the underlying disease, its exacerbations and chronic phase, and prevention and treatment of vascular problems.
Authors and Affiliations
Magdalena Celińska-Löwenhoff, Jacek Musiał
Keywords
Related Articles
- EP ID EP119955
- DOI -
- Views 84
- Downloads 0
ICD-11 – Projekt wytycznych diagnostycznych dla zaburzeń psychicznych: raport dla członków WPA
Planuje się, iż 11. edycja Międzynarodowej Klasyfikacji Chorób (ICD-11) zatwierdzona zostanie przez Światowe Zgromadzenie Zdrowia w maju 2018 r. Obecnie opracowywany jest rozdział dotyczący zaburzeń psychicznych. Projekt...
Porównanie wpływu anestetyków dożylnych stosowanych do znieczulenia w trakcie leczenia elektrowstrząsowego na bezpieczeństwo hemodynamiczne i przebieg zabiegów elektrowstrząsowych
Elektrowstrząsy (EW) są metodą leczenia szeroko stosowaną w chorobach psychicznych takich jak depresja, choroba afektywna dwubiegunowa, schizofrenia i psychoza schizoafektywna. Zaletą leczenia EW jest występowanie bardz...
Mental health problems in ethnic minority groups
The aim of this paper is to provide an insight into the specificity of mental health issues as experienced by ethnic minority groups’ representatives. A substantial body of evidence clearly indicates the differences in i...
Light therapy as a treatment for sexual dysfunctions – beyond a pilot study
Objectives. Seasonal trends were demonstrated in reproduction and sexual activity. Through the secretion of melatonin the pineal gland plays an important role in the neuroendocrine control of sexual function and reproduc...
S-adenosyl L-methionine in CNS diseases
S-adenosyl L-methionine (SAMe) is the natural, universal methyl group donor, participating in transmethylation reactions, known and commonly used as a dietary supplement since 1952. It plays an important role in the synt...