PYRAZOLINE SYNTHESIS THROUGH A CHALCONE INTERMEDIATE
Journal Title: International Journal of Drug Regulatory Affairs - Year 2014, Vol 2, Issue 4
Abstract
Pyrazoline derivatives, being used as potential medicinal agents, possess many important pharmacological activities and therefore they are useful materials in drug research. A series of these derivatives HT- 1 to HT- 6 containing 5-4-(chlorophenyl)-1,3-diphenyl- 4,5-dihydro-1H-pyrazole derivatives were synthesized, structures were confirmed using melting point, IR, NMR and MS and evaluated for their antibacterial activity using disc diffusion method at concentration 2mg/ml. The reference used was Amikacin and mostly, all synthesized compounds exhibited a significant antibacterial activity against Staphylococcus aureus (MTCC No. 96) as Gram positive bacteria, Staphylococcus epidermidis(MTCC No. 435) as Gram positive and Escherichia coli (MTCC No. 739) as Gram negative bacteria. It was observed that HT-1 and HT-2 possess good antibacterial potential against S. aureus, HT- 5 against S.epidermidis and HT-1 and HT-4against E. coli.
Authors and Affiliations
Md Hedaitullah, Ramanpreet Walia, Iqbal Khalid, Balwan Singh, Hussain Asif
Keywords
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- EP ID EP343113
- DOI 10.22270/ijdra.v2i4.153
- Views 137
- Downloads 0
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