QUANTITATIVE ANALYSIS OF ACETAMINOPHEN IN NUROMOL TABLETS BY HIGH PRESSURE LIQUID CHROMATOGRAPHY
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 1
Abstract
In this study quantitative analysis of Acetaminophen in Nuromol tablets by High pressure liquid chromatography were reported and discussed. The mobile phase as a mixture of the acetonitrile and water 25:75 v/v, the pH was adjusted to 2.5 with the help of phosphoric acid and the flow rate was set to 1.4ml/min; the UV detection was set to 207nm. The column used for the separation of the compounds was the C18 column. The results showed that the calibration curve was linear when plotted and was tested by running the standards from 1 to 10 micrograms/ml and best fit line was obtained. Accuracy achieved is 86.21% and different parameters for validation of a method like precision, limit of detection, limit of quantification, linearity, robustness, repeatability and reproducibility were calculated and the results were within the limits. It is therefore reasonable to conclude that the method can be used for quantification of the acetaminophen in Nuromol tablets by high pressure liquid chromatography.
Authors and Affiliations
Krupa Rani Gorthi Aravind G
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