Radiation Dose Enhancement Using Bi2S3 Nanoparticles in Cultured Mouse PC3 Prostate and B16 Melanoma Cells
Journal Title: NanoWorld Journal - Year 2015, Vol 1, Issue 3
Abstract
Gold nanoparticles (Au NPs) have been extensively investigated as contrast and dose enhancing agents. Bismuth sulfide (Bi2S3)-NPs have recently been investigated as contrast agents in radiology. In this study the dose enhancing effects of Bi2S3-NPs on radiated mouse PC3 prostate and B16 melanoma cells were examined. Equimolar concentrations of both Au and Bi2S3-NPs displayed equal dose enhancement with B16 cells, while the latter provided higher values with PC3 cells. At, equimolar concentrations there are less Bi atoms compared to Au in their respective NPs. Both NPs at comparable concentrations (0-1 mM) elicited similar cytotoxicity in PC3 mouse prostate cells. This study demonstrates that the less expensive Bi2S3 NPs are a viable alternative to Au NPs as a dose enhancing agent in clinical applications.
Authors and Affiliations
Merfat Algethami, Moshi Geso, Terrence Piva, Anton Blencowe, Lehui Lu, Kelong Ai, Peter D. Harty, Emily Gan
Keywords
Related Articles
- EP ID EP223094
- DOI 10.17756/nwj.2015-013
- Views 146
- Downloads 0
Effect of Thermal Annealing on the Optical and Structural Properties of the a-SiC Thin Films Deposited by DC Magnetron Sputtering
Hydrogenated Amorphous silicon carbide (a-SiC:H) thin films were prepared by DC magnetron sputtering technique using 6H-SiC polycrystalline target in a mixture of H2and Ar gas. They were thermally annealed at various tem...
Proceedings of the 2nd NanoWorld Conference in Boston (NWC-2017). Part III: Featured Presentations
The session on Nano-electronics was initiated by Prof. Xiaosheng Fang, Fudan University, China and Session talk were delivered by renowned experts -Prof. Seongil Im from Yonsei University, S. Korea on the “Two Dimensiona...
Stability and Radiation Damage of Protein Crystals as Studied by Means of Molecular Dynamics and Monte Carlo Simulation
Molecular Dynamics (MD) and Monte Carlo (MC) simulations of crystals can help in interpretation of experimental X-ray crystallography data. Particularly, they can be useful for understanding how various crystallization t...
Acknowledgement of Manuscript Reviewers NWJ Volume-1 (2015)
The Editors of NanoWorld Journal (NWJ) would like to express their tremendous gratitude to all those individuals who participated in the peer review process during the preparation of this Volume-1 (2015). Many reviewers...
Technology Transfer and Objective Assessment of Science and World Priority
Worthy of notice in this issue are for Society a critical analysis of post-Soviet space provided by one of the past closest associate of Gorbachiev [1], for Hardware new avenues in nanomaterials industry open by graphene...