Radiological Response Assessment in High Grade Gliomas: 3DCRT vs IMRT
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 8
Abstract
Objectives: To compare the radiological response in high grade glioma patients receiving post-operative radiation therapy via 3DCRT /IMRT technique with concurrent and adjuvant temozolomide. Materials and Methods: Twenty newly diagnosed histologically proven patients of high grade glioma in the age group of 18-70 years, post maximal resection were recruited and all patients received concurrent chemo-irradiation followed by adjuvant chemotherapy. All patients received a dose of 60 Gy in 30 fractions via 3DCRT/IMRT technique along with concurrent and adjuvant temozolomide according to Stupp’s regimen. Radiological response was assessed using Cho:NAA ratio in magnetic resonance spectroscopy done at 0,4th and 14th week of radiation therapy. Results: There was no statistically significant difference in the post radiation therapy radiological response with respect to Cho:NAA ratio between the 2 groups suggesting similar outcomes when high grade gliomas are treated with 3DCRT / IMRT technique. Conclusion: In patients diagnosed with high grade glioma treated by post-operative radiation therapy with concurrent and adjuvant temozolomide, radiation therapy can be delivered either with 3DCRT or IMRT technique without compromise in radiological response to treatment.
Authors and Affiliations
Dr Chaitanya S
Keywords
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