Raised concentrations of lipid peroxidation products (LPO) in pregnant women with impaired glucose tolerance
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2014, Vol 21, Issue 2
Abstract
introduction. Lipid peroxidation (LPO) results from oxidative damage to membrane lipids. Whereas LPO rises in normal pregnancy, the effect of gestational diabetes mellitus (GDM) on this process has not been clearly defined. materials and method. Fasting blood concentrations of malondialdehyde+4-hydroxyalkenals (MDA+4-HDA), as LPO index, TNFa soluble receptors (sTNF-R1 and sTNF-R2), and soluble adhesion molecules (sICAM-1, sVCAM-1), were measured in 51 women at 28 weeks of gestation. The women were divided according to the results of 50.0 g glucose challenge test (GCT) and 75.0 g oral glucose tolerance test (OGTT): Controls (n=20), normal responses to both GCT and OGTT; Intermediate Group (IG) (n=15), abnormal GCT but normal OGTT; GDM group (n=16), abnormal both GCT and OGTT. results. Glucose concentrations in women diagnosed with GDM were within the range of impaired glucose tolerance. There were no significant differences in concentrations of either TNF a soluble receptors R1 and R2, or sICAM-1 or sVCAM-1. LPO concentrations [MDA+4-HDA (nmol/mg protein)] were significantly higher in women with GDM than in the other two groups [64.1±24.3 (mean±SD), 39.3±23.1, 47.0±18.1, for GDM, IG and Controls, respectively; p<0.05]. In multivariate analysis, the only significant independent correlation was between LPO level and glucose at 120 minutes of OGTT (rs=0.42; p=0.009). conclusions. Oxidative damage to membrane lipids is increased in GDM and might result directly from hyperglycaemia. Physiological significance of this phenomenon remains to be elucidated.
Authors and Affiliations
Krzysztof C. Lewandowski, Nemanja Stojanovic, Martin Press, Susan Tuck, Andrzej Lewiński, Małgorzata Karbownik-Lewińska
Keywords
Related Articles
- EP ID EP80808
- DOI -
- Views 154
- Downloads 0
Dysfunction and pain temporomandibular disorder caused by impeded eruption of third mandibular molars
Introduction. There are reports in literature which indicate the connection between impacted third molars and occurrence of symptoms of craniomandibular dysfunctions and headaches. Objectives. The aim of this study was...
Effect of repetitive mowing on common ragweed (Ambrosia artemisiifolia L.) pollen and seed production.
Ambrosia artemisiifolia L (common ragweed) is a familiar roadside weed in southern Quebec (Canada) that produces large amounts of airborne pollen responsible for multiple rhino-conjunctivitis (hay fever) cases. As roadsi...
Epidemiology of human toxocariasis in Poland – A review of cases 1978–2009
Toxocariasis is a helminthozoonosis due to the infection of humans with larvae belonging to the [i]Toxocara[/i] genus. Humans become infected as a result of accidental consumption of infected eggs containing third stage...
Diffusion-weighted MRI of kidney in the diagnosis of clear cell renal cell carcinoma of various grades of differentiation
[b]Introduction[/b]. Renal cell carcinoma (RCC) is the most common malignant epithelial tumour of the kidney, accounting for 85–90% of all solid renal tumours in adults and comprising 1–3% of all malignant visceral neopl...
Impact of heavy metals on the female reproductive system
Introduction. It has been recognized that environmental pollution can affect the quality of health of the human population. Heavy metals are among the group of highly emitted contaminants and their adverse effect of livi...