Ramosetron vs Ramosetron with Dexmedetomidine for Prevention of Postoperative Nausea Vomiting and Shivering after Gynaecological Laparoscopic Surgery: A Comparative Study
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 4
Abstract
Background: Postoperative nausea and vomiting (PONV) and postanesthetic shivering (PAS) are common postoperative patient complaints that can be very distressing and may result in adverse physical outcomes. A combination therapy is more effective in dealing with PONV owing to its multifactorial etiology. Some antiemetics are reported to be effective in the management of PONV as well as PAS and pain. We evaluated the efficacy of dexmedetomidine added to ramosetron for prevention of PONV and shivering after gynaecological laparoscopic surgery. Methods: One hundred and sixty patients scheduled for gynecologic laparoscopic surgery were randomly allocated to two groups. The patients of first group (group R, n = 80) were given ramosetron 0.3 mg and 50 ml normal saline; and the patients of second group (group D, n = 80) were given ramosetron 0.3 mg and 1µ/kg dexmedetomidine diluted in 50 ml normal saline before anaesthesia. Results: Incidence of nausea, emesis and the need for rescue antiemetics was lesser in group D but the difference was insignificant. Incidence of shivering and interventions for shivering, one hour pain scores and total analgesic required in 24 hours were significantly lower in group D as compared to group R. Conclusions: Ramosetron 0.3 mg was as effective as combination of ramosetron 0.3 mg and dexmedetomidine 1µ/kg given before anaesthesia in reducing PONV. However, the combination of two drugs was more effective in reducing the incidence of post-operative shivering episodes, severity of pain, and total postoperative analgesic requirement compared to ramosetron alone in patients undergoing gynaecological laparoscopic surgery
Authors and Affiliations
Anjum Naz* MD
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