Rauwolfia Vomitoria and Vitamin E Restore Impaired Learning and Memory in 3-Nitropropionic Acid-Induced Oxidative Stressed Mice
Journal Title: International Journal of Biochemistry & Physiology - Year 2018, Vol 3, Issue 4
Abstract
The effect of root bark extract of Rauwolfia vomitoria (RV) and Vitamin E on neurobehaviour in 3-nitropropionic acid induced oxidative stress (OS) in mice was evaluated. Forty mice were divided into four groups (1-4) of 10 mice each. Animals in group one (control rats) received placebo treatment. Animals in group two were induced into oxidative stress by intraperitoneal injection (i.p) with 20 mg/kg body weight of 3-nitropropionic acid (3NP) once daily for 5 days. Animals in group three were pre-treated orally with 16 mg/kg body weight of root bark extract of R. vomitoria before being treated with 20 mg/kg body weight of 3NP (i.p) for 15 days. Animals in group four were pre-treated orally with 10mg/100g of Vitamin E (VE) before being treated with 20 mg/kg body weight of 3NP (i.p). The Morris water maze (MWM) test was done to determine the learning and memory status of the mice. There was significant (P<0.05) longer swim latencies particularly for days 2 and 3 of the acquisition training in the 3NP-induced oxidative stress group of mice when compared to the control group, RV treated 3NP OS group and vitamin E treated 3NP OS group. Findings from the reversal training swim latency, acquisition quadrant, retention quadrant duration, annulus acquisition frequency, frequency of annulus reversal and visible platform task showed a significant increase (P <0.05) in the swim latency of RV+3NP OS group when compared with the control and the VE+3NP OS group and a decrease in 3NP OS when compared with the VE+3NP OS and the control group. Treatment of these 3NP-induced oxidative stressed mice with root bark extract of R. vomitoria and Vitamin E reversed this cognitive learning and memory impairments toward normal, with R. vomitoria being more potent in ameliorating the effect of oxidative stress on learning and memory.
Authors and Affiliations
Eze Ejike D
Keywords
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- EP ID EP396451
- DOI 10.23880/ijbp-16000138
- Views 62
- Downloads 0
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