Re-Engraftment of Prior Cord Blood Graft in a Patient with Relapsed/Refractory Acute Myeloid Leukaemia following Haploidentical Transplantation
Journal Title: International Journal of Stem Cell Research and Transplantation (IJST) - Year 2015, Vol 3, Issue 7
Abstract
We report the case of a 32-year-old man with poor risk acute myeloid leukemia (AML) who received transplantation of an UCB graft following myeloablative conditioning but unfortunately relapsed after one year with complete loss of donor chimerism. As this patient did not have an HLA - matched sibling donor or a volunteer MUD, he went on to receive a second transplant with haploidentical CD34 cells from his mother following a non-myeloablative conditioning. After initial engraftment with the haploidentical donor cells, the patient became progressively pancytopenic and chimerism analysis revealed decreased level of cells derived from the haploidentical graft. However, there was a concurrent increasing ratio of the UCB derived cells from the first transplant. The patient had eventual recovery and stabilization of his full blood count and repeat chimerism analysis demonstrated successful re-engraftment with the previous UCB graft. To the best of our knowledge, no such similar cases have been reported in the literature. Thus, cord blood cells from a prior transplant could remain present in small quantities at the phase ofleukemia relapse and re-emerge to establish long term hematopoiesis even after graft failure from a subsequent haploidentical transplant.
Authors and Affiliations
Lim Wei Inng Francesca Lorraine
Keywords
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- EP ID EP197102
- DOI 10.19070/2328- 3548-1500021
- Views 86
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Re-Engraftment of Prior Cord Blood Graft in a Patient with Relapsed/Refractory Acute Myeloid Leukaemia following Haploidentical Transplantation
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