Re: Primary Plasma Cell Leukaemia: Case report and review of the literature

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Re: Primary Plasma Cell Leukaemia: Case report and review of the literature

Journal Title: Sultan Qaboos University Medical Journal - Year 2018, Vol 1, Issue 4

Abstract

I read with interest the recent case report by Singh et al. published in the August 2018 issue of SQUMJ, in which the authors describe a 69-year-old male patient with rectal bleeding associated with pallor, dyspnoea and chest pain.1 Laboratory tests showed microcytic hypochromic anaemia, leukocytosis, low platelets and a high erythrocyte sedimentation rate. Elevated levels of urea, creatinine, uric acid, immunoglobulin D, kappa light chains and β2-microglobulins were also detected, while abdominal, thoracic and skeletal imaging did not show any abnormalities.1 A bone marrow aspirate revealed 61% atypical plasma cells. Subsequently, a diagnosis of primary plasma cell leukaemia (PCL) was confrmed and bortezomib-based chemotherapy was administered, resulting in a good response.1 Myeloma cells can travel to the peripheral blood if expression of the cell adhesion molecule cluster of diﬀerentiation (CD)56 decreases.2,3 Along with CD19, CD20 and CD23 positivity, this phenomenon is often observed among patients with primary PCL, while the positive expression of CD28 and interleukin-6 are considered important in secondary cases.2,3 Leukocytosis, high levels of lactate dehydrogenase and β2-microglobulins and the presence of bone lesions can help to diﬀerentiate primary PCL from myeloma.4 Singh et al. therefore highlighted the need for consensus guidelines in primary healthcare for the purposes of early diagnosis and prompt and adequate treatment.1 Other case reports have also emphasised the diagnostic pitfalls associated with unsuspected cases of myeloma, rib plasmacytoma, multiple myeloma and secondary PCL.4–6 Tese cases may help to enhance suspicion of plasma cell malignant disorders among primary healthcare workers. Dos Santos et al. reported a 53-year-old female patient with multiple myeloma and secondary PCL; the patient had 25% plasma cells in a bone marrow aspirate and positive expressions of lambda light chains, CD56 and CD20 as well as 23% circulating peripheral blood plasma cells.4 She had high levels of urea and creatinine and was hypercalcaemic and anaemic. An X-ray showed radiolucent speckled areas in the humeral diaphysis with no evidence of organomegaly or lymphadenopathy.4 A diagnosis of leukaemia was made, based on the presence of >2,000/mm3 circulating plasma cells, some of which were dysplastic. Subsequently, the patient demonstrated signifcant clinical improvement following treatment with dexamethasone, cyclophosphamide, thalidomide, cisplatin, doxorubicin and etoposide.4 Another case report described a 65-year-old female patient who was diagnosed with rib plasmacytoma, overt immunoglobulin (Ig)-A-producing multiple myeloma and hyperviscosity syndrome.5 She had a history of dyspnoea and a mental disorder and subsequently developed chronic renal failure, respiratory disturbance and heart failure. Bio-chemistry tests showed elevated urea, creatinine and calcium levels and β2-microglobulins; in addition, she was anaemic and her IgA and kappa light chain levels were 8,917 mg/dL (normal range: 153–359 mg/dL) and 2,990 mg/dL (normal range: 625–1,668 mg/dL), respectively.5 Te presence of >50% plasma cells with basophilic cytoplasm, eccentric nuclei and large nucleoli in a bone marrow biopsy established the diagnosis of multiple myeloma. Te patient was treated with dexamethasone and underwent plasmapheresis without improvement.5 Finally, dos Santos et al. reported a 64-year-old male patient who presented with dizziness, fatigue, dyspnoea, lumbar pain and high levels of calcium, urea and creatinine.6 Multiple osteolytic lesions were detected in the cranium and lumbar spine, in addition to a monoclonal peak in the gamma region and high levels of IgG. A bone marrow aspirate revealed >40% plasma cells.6 Te patient was eventually diagnosed with multiple myeloma at a late stage, due partly to a history of activities resulting in overload on the axial skeleton because of his profession as a construction foreman, as well as nonsteroidal anti-inﬂammatory drug abuse. He underwent chemotherapy which resulted in an unsatisfactory response.

Authors and Affiliations

Vitorino M. dos Santos

Keywords

Primary Plasma Cell Leukaemia

Immunotherapy for B-Cell Neoplasms using T Cells expressing Chimeric Antigen Receptors From antigen choice to clinical implementation

Immunotherapy with T cells expressing chimeric antigen receptors (CAR) is being evaluated as a potential treatment for B-cell neoplasms. In recent clinical trials it has shown promising results. As the number of potent...

EP ID EP37492
DOI http://dx.doi.org/10.18295/squmj.2018.18.04.026
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