Real-life Outcomes of Tenofovir Disoproxil Fumarate Monotherapy in Nucleos(t)ide Analogue-naive and Nucleos(t)ide Analogue-experienced Chronic Hepatitis B Patients: A Single-center Experience
Journal Title: Viral Hepatitis Journal - Year 2016, Vol 22, Issue 3
Abstract
Objective: The aim of the study was to evaluate the long-term results of treatment efficacy and safety in nucleos(t)ide analogue-naive (NA-naive) and NA-experienced chronic hepatitis B (CHB) patients receiving tenofovir disoproxil fumarate (TDF) therapy. Materials and Methods: Data of 99 patients treated with the diagnosis of CHB (hepatitis B surface antigen-positive for more than 6 months) with TDF monotherapy between February 2008 and May 2014 were evaluated retrospectively. Results: In total, 99 patients (median age: 50 years, 68.7% male, 21.2% hepatitis B e-antigen-positive) were included in the study. Thirty patients were NA-naive and 69 patients were NA-experienced. No significant difference was determined between NA-naive and NA-experienced patients regarding the rate of achieving complete virological response at the 1st, 2nd, 3rd, 4th, and 5th years of the treatment (p>0.05). Additionally, no significant difference was determined between NA-naive and NA-experienced patients regarding achieving a biochemical response rate at the 1st, 2nd, 3rd, 4th, and 5th years of the treatment (p>0.05). In our study, resistance at the end of the 5th year was not found. No patient required discontinuation of the treatment due to adverse effects during treatment. Conclusion: Data analysis indicates that TDF monotherapy provides an efficient viral suppression in NA-naive and NA-experienced patients at the end of the 5th year of the treatment.
Authors and Affiliations
Pınar KORKMAZ, Figen ÇEVİK ÇAĞLAN, Nevil AYKIN, Hasan NAZ, Onur TOKA
Keywords
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- EP ID EP228496
- DOI 10.4274/vhd.94830
- Views 76
- Downloads 0
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