Real-life treatment patterns and medication costs in patients with hypertension treated with ramipril monotherapy or ramipril loose and fixed combinations in Poland
Journal Title: JOURNAL OF HEALTH POLICY & OUTCOMES RESEARCH - Year 2015, Vol 8, Issue 2
Abstract
Background: Real-World Evidence (RWE) provides insights into patient outcomes reflecting current practices under existing healthcare system conditions. Longitudinal patient data are a source of information that can be used to track treatments for anonymised individual patients over time. Arterial hypertension is one of the most common chronic diseases in Poland, leading to serious complications, especially if undiagnosed and not properly controlled. Fixed-dose combinations of antihypertensive drugs become more and more popular in the treatment of hypertension. The objective of this study was to analyze real-life treatment patterns and medication costs in patients with hypertension treated with the most popular ACEI in Poland - ramipril, in monotherapy, loose and fixed combinations. Methods: This analysis was based on the longitudinal prescription database (IMS “LRx”) of individual, anonymized patients structured by product, prescribing doctor specialty and patient age group and sex, sourced from dispensing transactions of 3367 chain and non-chain pharmacies, in the Polish open-care market. The period of analysis covers 20 months (January 2014 – August 2015). It is based on 1 488 053 patients and 9 023 582 prescriptions. Cost calculations were performed from payer’s and patient’s perspectives. Results: Owing to the availability of multiple treatment options, patterns in hypertension treatment in Poland are very complex, even when considered only at the molecule level. Furthermore, switching to fixed-dose combination therapy based on ramipril resulted in savings for patients as well as the public payer. Conclusion: Wider use of fixed-dose combinations is a cost saving option both for patients and the public payer.
Authors and Affiliations
Marcin Czech, Zbigniew Jasiński, Dominika Krupa
Keywords
Related Articles
- EP ID EP192165
- DOI 10.7365/JHPOR.2015.2.4
- Views 108
- Downloads 0
The assessment of the impact of thrombocytopenia symptoms on the patients’ daily activities with the use of TSIDAV vignette
Objective: Assessment of the impact of thrombocytopenia symptoms on patients’ daily activities using vignettes. Methods: Vignettes were used to collect information from adult patients and children’s caregivers in order...
Treatment and prevention of bleeding in adult hemophilia A patients with inhibitor – economic analysis.
Hemophilia A is caused by an absence or deficiency of coagulation factor VIII. Patients with hemophilia may experience recurrent spontaneous hemarthroses or internal bleeding. Following the treatment with factor VIII con...
Primary immunodeficiencies – epidemiology, spending on therapy, diagnostic and therapeutic needs in Poland
Abstract Primary immunodeficiencies (PID) are a heterogeneous group of over 300 diseases of the immune system characterised by its disfunction, and in consequence by chronic or recurrent infections, autoimmunity, aller...
Cost-effectiveness analysis of methods of diagnosis of tb infection in russian regions by use of recombinant tb allergen in children and adolescents
Background. Russia is among the countries with a high burden of TB. A new diagnostic method for TB has been developed, called ‘recombinant tuberculosis allergen’ or RTA (Diaskintest®), which has a similar cost and method...
RWE in Europe – An Analysis
Background – This paper outlines findings from four roundtable discussions involving a number of stakeholders. They aimed to improve understanding of the use of real world evidence (RWE) across Europe. They focused on th...