Receptors of mammalian trace amines
Journal Title: The AAPS Journal - Year 2006, Vol 8, Issue 1
Abstract
The discovery of a family of G-protein coupled receptors, some of which bind and are activated by biogenic trace amines, has prompted speculation as to the physiological role of these receptors. Observations associated with the distribution of these trace amine associated receptors (TAARs) suggest that they may be involved in depression, attention-deficit hyperactivity disorder, eating disorders, migraine headaches, and Parkinson's disease. Preliminary in vitro data, obtained using cloned receptors, also suggest a role for TAARs in the function of hallucinogens.
Authors and Affiliations
Anita H. Lewin
Keywords
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- DOI 10.1208/aapsj080116
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