Red Cell Distribution Width to Platelet Ratio (RPR) - A Predictive Index of Ductal Closure in Preterm Neonates
Journal Title: The Indian Journal of Maternal-Fetal and Neonatal Medicine - Year 2019, Vol 6, Issue 1
Abstract
Introduction: Inflammatory processes have been proposed to have a role in maintaining the patency of Ductus Arteriosus. Red cell distribution width (RDW) levels escalate in the presence of inflammation. Our aim was to evaluate the role of red cell distribution width to platelet ratio (RPR) in predicting the closure of hemodynamically significant patent ductus arteriosus (hsPDA) in response to paracetamol therapy in preterm neonates. Methods: A prospective comparative study was conducted on preterm neonates less than 37 weeks of gestation diagnosed with hsPDA after obtaining Institutional ethical clearance and detailed informed consent from the parents. All the neonates were treated with oral paracetamol for 3 days and then reassessed for closure of PDA. RDW and platelet counts were analyzed within 24 hours of life and RPR was then calculated. Preterms with sepsis, anemia, asphyxia, major congenital malformations were excluded from the study. Results: 108 preterm neonates were admitted to the NICU during the study period, of which 50 neonates were included in the study. Ductus closed in 28 preterms following treatment by day 3. Mean RPR was found to be lower in the neonates in which the ductus closed by day 3. An RPR cut off of 0.12 having AUC of 0.769 had sensitivity of 68% and specificity of 86% with PPV and NPV of 79% and 77% respectively for the prediction of Ductus Arteriosus closure. Conclusion: Our study shows that RPR can be used as a simple and effective screening tool in foreseeing the successful closure of hsPDA with pharmacotherapy.
Authors and Affiliations
Sahana Panambur
Keywords
Related Articles
- EP ID EP628016
- DOI 10.21088/ijmfnm.2347.999X.6119.5
- Views 85
- Downloads 0
To Study Impact of Advanced Maternal Age on Pregnancy Outcome at Tertiary Care Center
Introduction: ”Successful motherhood is the unique achievement in woman’s life” Advanced maternal age is defined as age 35 years or more for the mother at the time of delivery. Across the world, there is a rising trend a...
A Study of Heart Disease in Pregnancy and the Associated Complications
Introduction: Pregnancy associated with any medical illness becomes a challenge for an obstetrician. Cardiac disease is one such medical illness which complicates 0.1 – 4% of pregnancies. Aims and objectives: 1) to study...
Study on Prevalence and Risk Factors for Persistent Pulmonary Hypertension in Ventilated Term Newborns in a Tertiary Care Neonatal Unit
Context: Persistent pulmonary hypertension (PPHN) is a serious neonatal illness, with significant morbidity and mortality. Limited data are available about PPHN in our set up and thus this study was done. Aims: To assess...
Incidence of Hypoglycaemia in SGA Neonates in First 48 hours of Life
Objectives: To detect the incidence of hypoglycaemia in Small for gestateonal age (SGA) neonates. Design: Hospital based prospective study in a maternitycentre in south India. Inclusion criteria: all inborn SGA neonates...
Rudimentary Horn Pregnancy: A Diagnostic Dilemma
Background: Rudimentary horn pregnancy carries grave consequences for the mother. Though sonography and magnetic resonance imaging can clinch the diagnosis in early stages, majority of the cases are diagnosed only after...