Red Cell Parameters in G6PD Deficient Individuals during Normal Steady State
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 1
Abstract
Background: G6PD enzyme deficiency has X-linked inheritance with variable prevalence in different population groups. Deficient subjects enjoy normal health unless were exposed to oxidative stress that yields haemolytic crises and may lead to fatalities. Aim/objective: Few reports available on haematological parameters among G6PD deficient subjects in steady state; the issue is addressed in present report. Research design: Pairs of spouses from Vatalia Prajapati community, known for high prevalence of G6PD deficiency, were selected for prospective analysis. Measurement of red cell indices and quantitative assay for G6PD enzyme were carried out using automated devices. The parameters were correlated among the subjects classified as per level of enzyme activities (as EU/gHb at 37°C) shown, i. e. Normal, >9 (male and female); Heterozygote, 2.75 – 8.99 (female) and Deficient, <2.75 (male hemizygote and female homozygote). The statistical analysis was carried out using Microsoft Excel 2010 and online software. Results: Among 148 subjects studied, 40 of 77 male and 25 of 71 female were deficient for G6PD enzyme. Between normal and enzyme deficient groups, the male displayed significant difference in the mean values for RBC count, Hb and PCV, while the female showed significant difference only in the RBC count. Interestingly, the mean values for all the parameters significantly differ among the heterozygote and homozygote for G6PD deficiency. Increased MCV was significantly associated with heterozygote as compared to the normal. Conclusion: Although G6PD deficiency does not show any illness in normal steady life, the red cell parameters do show some deviation from normal.
Authors and Affiliations
Dr. Sanmukh R. Joshi
Keywords
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