REDUCED PLASMA ANTIOXIDANT LEVELS IN SMOKING ASTHMATICS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 1
Abstract
The imbalance in antioxidants is thought to play an important role in the pathogenesis of bronchial asthma. The present study was undertaken to evaluate the status of lipid peroxidation and antioxidants as biomarkers in human plasma. The extent of lipid peroxidation as evidenced by the formation of thiobarbituric acid reactive substances (TBARS) and the status of the antioxidants by reduced glutathione (GSH) in the smokers with and without asthma. The mean TBARS levels were higher among smokers with asthma (2.97±1.09) when compared with control smokers (0.75 ±0.81). The mean GSH level were higher in control non-smokers (0.172±0.21) compared to asthma smokers (0.032±0.03) and non smokers (0.061±0.06). Measured parameters confirm that cigarette smoke mediated oxidative stress could represent the primary causative factor in the pathogenesis of asthma.
Authors and Affiliations
G Rajalakshmi , S Sudha
Keywords
Related Articles
- EP ID EP92515
- DOI -
- Views 111
- Downloads 0
MORPHO-ANATOMICAL AND PHYSICOCHEMICAL STUDIES OF DRIED SEEDS OF DATURA FASTUOSA LINN.
In the present study, dried seeds of Datura fastuosa Linn. (Solanaceae), a rich source of tropane alkaloids, has been explored for morpho-anatomical and physicochemical studies. Datura fastuosa seeds has been investigate...
CONCEPTUAL STUDY OF THE EFFECT OF ‘UTTARBASTI’ IN ‘VANDHYATVA’ WITH SPECIAL REFERENCE TO CERVICAL FACTOR OF INFERTILITY
The most disappointing feeling for a woman is, if she could not be a mother. The present day’s life style of women is very stress full, unhealthy and unhygienic due to unawareness, hectic and fast running schedule. Vandh...
PHARMACOGNOSTICAL AND PHYTOCHEMICAL EVALUATION OF LINARIA RAMOSISSIMA (WALL.) JANCH. (SCROPHULARIACEAE) STEM
Linaria ramosissima (Wall.) Janch. (Scrophulariaceae) commonly known as ‘Kanoti’ & ‘Bhintgilodi’ is a reputed folklore drug. Literally ‘Kanoti’ means ‘ear’ representing ear shaped leaves of the plant. The drug is rep...
N-NITROSODIMETHYLAMINE AS A HAZARDOUS CHEMICAL TOXICANT IN DRINKING WATER
Nitrosamines is a family of potent carcinogens, have been of concern for many decades due to their occurrence in foods, industrial workplace environments, and as groundwater contaminants. Human exposure to nitrosamines c...
PHYTOCHEMICAL CONSTITUENTS OF PHYLLANTHUS SPECIES (EUPHORBIACEAE) FROM EASTERN GHATS OF ANDHRA PRADESH, INDIA
The present paper deals with phytochemical constituents of Phyllanthus species (Euphorbiaceae). The petroleum ether, methanol and water extracts of different parts of 15 species of Phyllanthus were screened for phytochem...