Reduced Serum Nitrate in Individuals with Primary Hypertension
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 9
Abstract
Background and objectives: Primary or essential hypertension (PHTN ) is the most prevalent form of hypertension accounting 90 % of all cases of hypertension . Evidence suggests that Nitic oxide (NO) plays a major role in regulating blood pressure and that impaired NO bioactivity is an important component of hypertension. Hence this study is taken up to estimate nitrate levels in Primary Hypertension patients compared with healthy individuals. Methodology: The present study was conducted in the Department of Physiology, Al-Ameen Medical College, Bijapur and District Hospital, Bijapur. Thirty five (35) Primary Hypertension Patients (17 male, 18 female) between 35 to 65 yrs age and Thirty nine (39) healthy individuals, controls (20 male, 19 female) between 38 yrs to 65 yrs age visiting Al-Ameen Medical College Hospital, Bijapur and District Hospital Bijapur were selected. Serum Nitrate was estimated by GRIESS METHOD . Statistical analysis was done www.jmscr.igmpublication.org Impact Factor 3.79 ISSN (e)-2347-176x Dr Zaheera Sultana S et al JMSCR Volume 2 Issue 9 Sptember 2014 Page 2249 JMSCR Volume||2||Issue||9||Page 2248-2255||September-2014 2014 by ANOVA Results: Statistically significant variations were found in parameters like age, Ht, Wt, BSA, BMI, PR, SBP, DBP, Serum Nitrate levels in controls and Primary Hypertension patients. Interpretation and Conclusion: In the present study the mean ± SEM of Serum Nitrate in controls was found to be 49.93 ± 1.01 μ mol / lt, and primary hypertension patients was 33.6 ± 0.02 μ mol / lt. . It was found Serum Nitrate levels of PHTN patients were lower when compared with the controls, these difference were found to be statistically significant ( t =12.165, p= 0.0000 ) . Hypertension can produce direct toxic effect on human endothelium; impairment of the release of NO from vascular endothelial cells may thus contribute to the reduced plasma nitrogen oxide concentrations in patients with essential hypertension. . Increased production of superoxide anions, which rapidly deactivate NO, is a characteristic feature of experimental models of hypertension, and plasma indexes of lipid peroxidation are increased in patients with hypertension.
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Dr Zaheera Sultana S
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