REGENERATION OF ARTI CULAR CARTILAGE UNDE R THE IMPLANTATION O F BONE MATRIX
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2015, Vol 4, Issue 3
Abstract
Background: The amage or loss of articular cartilage is costly medical problem. The purpose of this work - morphological analysis of reparative chondrogenesis when implanted in the area of the knee joint cartilage of granulated mineralized bone matrix. Material and Methods: The characteristic features of the knee cartilage regeneration studied experimentally in pubertal Wistar rats after modeling a marginal perforated defect and implantation of granulated mineralized bone matrix obtained according to original technology without heat and demineralizing processing into the injury zone. Results: This biomaterial established to have pronounced chondro- and osteoinductive properties, and to provide prolonged activation of reparative process, accelerated organotypical remodeling and restoration of the articular cartilage injured. Conclusion: The data obtained demonstrate the efficacy of МВМ in clinical practice for the treatment of diseases and injuries of the articular cartilage.
Authors and Affiliations
Yuri M. Iryanov| Head of the Laboratory of Morphology, Doctor of Biological Sciences, Professor. Russian Ilizarov Scientific Center Restorative Traumatology and Orthopaedics (RISC RTO), Kurgan, Russia, Nikolay A. Kiryanov| Head of Department of Pathology of Izhevsk State Medical Academy, Doctor of Medical Science, Professor, Russia, Corresponding author email: kirnik@list.ru, Olga V. Dyuriagina| A Senior Researcher, Laboratory of Purulent Osteology and Limb Defect Filling, RISC RTO, Candidate of Veterinary Sciences, Russia, Tatiana Yu. Karaseva| Head, Department of Orthopaedics, RISC RTO, Candidate of Medical Sciences, Russia, Evgenii A. Karasev| A Researcher, Department of Orthopaedics, RISC RTO, Candidate of Medical Sciences, Russia
Keywords
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- EP ID EP11437
- DOI 10.5958/2319 - 5886.2015.00103.4
- Views 287
- Downloads 12
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