Relation & Association of Mean Ocular Perfusion Pressure in Primary Open Angle Glaucoma
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 5
Abstract
Purpose: To find out relationship of mean ocular perfusion pressure(MOPP), Systolic ocular perfusion pressure (SPP) & diastolic ocular perfusion pressure with occurrence of primary open angle glaucoma(POAG) Study Design: Hospital based cross sectional study Study period: August ‘2016- February ’2017. A period of 6 months. Setting: Sankara eye hospital, krishnankoil, tamilnadu. Method: In a period of 6 months we examined total 836 patients of 40-80 years age group from southern part of Tamilnadu, of which 431 patients were male & 405 were female. All patients are evaluated with dilated fundus bio microscopy with +90D lens,IOP measurement by applanation tonometer,gonioscopy by goldman 4 mirror goniolens& Humphrey 30-2 perimetry test. Only primary open angle glaucoma patients were included. Blood pressure was checked in each patient with digital BP measuring instrument. After collecting all data MOPP, SPP, DPP were calculated. Result: The mean IOP in POAG group was 21.8± 8.4 mm of Hg, whereas in normal group it was 15.7± 4.2 mm of Hg. MOPP in POAG patients was 59.9± 9.4 mm of Hg & normal group 62.7 ± 10.4 mm of Hg. SPP & DPP in POAG patients were 136.2± 15.4 & 62.2±11.8 mm of Hg. In normal group SPP & DPP was 134.6±18.4 mm of Hg & 64.6±10.6 mm of Hg respectively. The relation of OPP in POAG was done by multivariate logistic regression analysis, where pressure related factors i.e. MOPP, SPP, DPP were taken as variable. Lower DBP, lower MOPP was significantly associated with OAG risk. Lower DBP (OR= 1.65; 95% CI, 1.12 –2.82, comparing persons in the lowest quartile with those in highest quartile [Q1 vs. Q4] of DBP), lower MOPP (OR=1.63; 95% CI, 1.02–2.85; [Q1 vs. Q4]) and lower DPP (OR,=1.56; 95% CI, 1.23–2.92; [Q1 vs. Q4]) were significantly associated with OAG risk. Higher SBP wasnot associated with increased risk of glaucoma(p= 0.64)
Authors and Affiliations
Dr. Anwesha Manna, Dr. Vishalakshi Subramanium, Dr. Sudha Jeyaram
Keywords
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- EP ID EP598210
- DOI 10.9790/0853-1605125458.
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