Relationship Between Bone Turnover and Bone Density in Perimenopausal and Early Postmenopausal Women
Journal Title: Türkiye Osteoporoz Dünyasından - Year 2009, Vol 15, Issue 1
Abstract
Aim: The aim of this study was to investigate the relationship between the bone turnover and bone density in perimenopausal and postmenopausal women. Material and Methods: Forty-two healthy women, 16 perimenopausal and 26 early postmenopausal were included in the study. Bone density at the spine and proximal femur was measured by dual energy x-ray absorptiometry (DXA). Routine serum biochemical tests were performed. Serum alkaline phosphatase (ALP) level was measured. Bone turnover markers including serum osteocalcin (OC) and and type I collagen crosslinked C-terminal telopeptide (CTX) levels were measured. Results: Mean age was 48±4 years, body mass index (BMI) was 27.87±4.26 kg/m2. Mean age at menopause was 45±9 years, time after menopause was 3.23±1.9 years in early postmenopausal group. Serum OC and CTX levels were 19.23±7.52 mg/dl and 0.58±0.35 mg/dl, respectively. CTX level was high in 21.6% (9 women) of the study subjects, whereas OC level was high in 36.3% (15 women) of the group. Osteoporosis and osteopenia rates in the study subjects were 11.9% and 40.4%, respectively. BMD values at the spine and proximal femur did not show correlation with bone turnover markers. Serum ALP level showed statistically significant negative correlation with femoral neck BMD (p=0.003). BMI showed statistically significant correlation with BMD values at femoral neck and total femur (p=0.033, p=0.001). There were no statistically significant difference in terms of serum OC and CTX levels and BMD values at spine and hip between the perimenopausal and early postmenopausal groups (p>0.05). Conclusion: As our results there was no correlation between bone turnover markers and bone density at spine and hip in perimenauposal and early postmenauposal women. (From the World of Osteoporosis 2009;15:7-10)
Authors and Affiliations
Nurdan Paker, Derya Buğdaycı, Betül Kaya, Didem Dere, Demet Tekdöş
Keywords
Related Articles
- EP ID EP84352
- DOI -
- Views 77
- Downloads 0
Diabet ve Osteoporoz
Osteoporoz kemik mikromimarisinde bozulma ve kemik yoğunluğundaki düşme ile kemik kırılganlığının arttığı bir iskelet hastalığıdır. Diabet ve osteoporoz ilişkisini gösteren çalışmalar az ve tartışmalıdır. Diabetle oluş...
Relationship Between Bone Turnover and Bone Density in Perimenopausal and Early Postmenopausal Women
Aim: The aim of this study was to investigate the relationship between the bone turnover and bone density in perimenopausal and postmenopausal women. Material and Methods: Forty-two healthy women, 16 perimenopausal and...
Proksimal Femur Total Kemik Mineral Yoğunluğu Değerlerine Göre Normal ya da Osteopenik Bulunan Postmenopozal Kadınlarda Femur Proksimalı Bölgesel Ölçümlerine Göre Osteoporoz ve Osteopeni Sıklığı
Proksimal femur Dual-X Ray Absorpsiometri (DEXA) incelemesi yüksek doğruluk ve kısa görüntüleme süresi nedeniyle osteoporoz tanısında tercih edilen yöntemdir. Bu çalışmada proksimal femur total kemik mineral yoğunluğu (K...
150 Sağlıklı Erişkin Erkekte Metakarpal Kemik Kitlesi – El Kavrama Gücü İlişkisi
Kemik gücünün belirleyicileri arasında öncelikle kemik yoğunluğu ve kas gücü yer alır. El kavrama ölçümü pahalı değildir, non-invazivdir ve metakarpal kemik yoğunluğu ölçümüyle birlikte değerlendirildiğinde kemik minera...
Fibromiyalji Hastalarında Kemik Mineral Yoğunluğu ile Serum D Vitamini Düzeyinin Ağrı ve Yaşam Kalitesi Üzerine Etkisi
Amaç: Bu çalışmanın amacı premenopozal Fibromiyalji Sendromlu (FMS) hastalarda Kemik Mineral Yoğunluğu (KMY) ve serum 25-OH-Vitamin D3 düzeylerini belirlemek, bunların FMS’li hastalarda ağrı ve yaşam kalitesi üzerine etk...