Relationship between Diabetic Retinopathy and Methylenetetrahydrofolate Reductase Gene Polymorphism
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2017, Vol 67, Issue 0
Abstract
Purpose: To assess MTHFR rs1801133 (C677T) gene polymorphism in diabetic patients as a risk factor for diabetic retinopathy and to establish the changes in Platelet indices & count in diabetic patient as compared to the healthy control group. Patients and Methods: The study included 40 patients with Type 2 Diabetes Mellitus. They were divided into 2 equal groups, 20 patients with Diabetic Retinopathy, 20 patients without Diabetic Retinopathy. Patients were selected from those attending the outpatient Ophthalmology Unit and Diabetes Clinic of Al-Zahraa University Hospital in the period from June 2014 to June 2015. Their ages ranged between 34 to 66 years old. They were 14 males and 26 females. Twenty cases apparently healthy individuals were selected as a control group. All cases were subjected to full history taking and complete ophthalmological examination. Also laboratory investigations were done including complete blood picture, kidney and liver function tests, coagulation profile, urine analysis, lipid profile, fasting and postprandial blood sugar and Genetic study for detection of MTHFR gene C677T mutation (rs 1801133)by real time PCR. Results: In all diabetic patients the mutant homozygous TT showed a highly statistically significant increase in FBS (p=0.000), PPBS (p=0.000), HbA1C (p=0.000) and cholesterol (p=0.001) as compared to wild type. Also in all diabetic patients the mutant homozygous TT showed a highly statistically significant increase in FBS (p=0.002), PPBS (p=0.001), HbA1C (p=0.019) and cholesterol (p=0.012) as compared to heterozygous mutant type. Conclusion: The homozygous mutant type (TT) of rs1801133 was detected in 10% of DR patients group while absent in DWR group and the control group. The heterozygous mutant type (CT) was increased in DR group (50%) as compared to DWR group (35%) and the control group (25%).
Authors and Affiliations
Jihan Abdallah M1; Seham Mohamed2; Hamdia Ezzat A2; Eman Salah M2
Keywords
Related Articles
- EP ID EP499470
- DOI -
- Views 109
- Downloads 0
Effect of Chest Physical Therapy Modalities on Oxygen Saturation and Partial Pressure of Arterial Oxygen in Mechanically Ventilated Patients
<strong>Background: </strong>Chest physical therapy plays an important role in increasing Pao2 and SaO2 among ICU patients which is considered as a good indicator for the general improvement of the patient besides decrea...
Hair loss among Saudi Females, Taif University, Taif, Saudi Arabia
<strong>Background: </strong>the female pattern hair loss is the most common cause of hair loss in female, which is androgenic pattern, medical treatment such as anti-androgenic therapy and topical preparation may simply...
The Relationship between Abdominal Aortic Calcification and Cardiac Abnormalities in Hemodialysis Patients
Background: Abdominal aortic calcification (AAC) is a marker of subclinical atherosclerotic disease and an independent predictor of subsequent vascular morbidity and mortality. Aim of the work: This study was conducted t...
The Prevalence of Dysmenorrhea among Women
Menstrual disorders and abnormal uterine bleeding are common worries of young women. Complaints comprise menses that are: too painful (dysmenorrhea), prolonged and heavy (menorrhagia, or excessive uterine bleeding), or a...
Motives and Knowledge towards Bariatric Surgeries among Adults in Al-Madinah, Saudi Arabia, 2018`
Background: recent studies have shown the effectiveness of bariatric surgery in improving severe obesity, it’s associated with co-morbidities and the level of mortality. Objective: this study aimed to determine the motiv...