Relationship between glycosylated haemoglobin and risk of microalbuminuria in patient with type II diabetes mellitus
Journal Title: Medpulse International Journal of Biochemistry - Year 2017, Vol 4, Issue 3
Abstract
Problem Statement: Nephropathy is one of the complications of type 2 diabetes mellitus that could lead to end‑stage renal disease. Persistent microalbuminuria is the best predictor of high risk of developing diabetic nephropathy. The relation between HbA1c and microalbuminuria with the duration of diabetes is not clear. Methods: It was prospective Study, The subjects were chosen from the Out Patient Department and Indoor Patient Department of Medicine, Anugrah Narayan Magadh Medical College, Gaya. Bihar. The duration of study was from December 2016 to August 2017. The study group consists hundred cases of 20-60 years age group from rural and urban area after following the exclusion and inclusion criteria. We divided hundred patients in four age groups i.e. 20-30 years, 31-40 years, 41-50 years and 51-60 years of age group. A short history and clinical examination of the patients were obtained regarding the blood pressure, history of smoking, alcohol intake and after taking the verbal consent of the patient after that blood and Urine samples were collected. Blood and Urine samples were tested in the Department of Biochemistry, Result: In the present study we divided total 100 patients in four age groups out of them 58 were male and 42 we female. Maximum number of patients belongs to 51-60 years of age group. Among them 34%17 were male and 26%13 were female. The present study comprises total 100 patients among them 24 (48%) were male and 26 (52%) were female who belong to urban area and 34 (68%) were male and 16 (32%) were female who belong to rural area respectively. we found that in urban area 42%21 male patients and 3%6 female patients were smokers. Likely in rural area 64% (32) male patients and 4% (2) female patients were smokers. Rest of the patients of our study were non smokers. The correlation between HbA1c and Micro Albumin of our study. The mean and ±SD was 7.5200 ±1.53 and 36.1330 ±53.79 for HbA1c and Micro albumin respectively. And we found the correlation statistically significant. Conclusion: Present study showed a positive correlation of microalbuminuria with duration of diabetes and level of glycaemic control (measured by HbA1c levels), which is in accordance with many previous reports. Also, presence of concomitant hypertension and smoking were important risk factors in early development of nephropathy. Therefore, regular screening for microalbuminuria in addition to continuous HbA1c estimation are important tools in the management of DM.
Authors and Affiliations
Yogesh Krishna Sahay, Madhu Sinha
Keywords
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