Relationship between gut microbiota and hepatocellular carcinoma through two-sample Mendelian randomization study
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 6
Abstract
Objective To investigate the potential association between 221 types of gut microbiota and hepatocellular carcinoma (HCC) using a two-sample Mendelian randomization approach, providing insights for the prevention and treatment of HCC. Methods The HCC data (n=197 611) from the IEU OpenGWAS database was used as outcome data, while gut microbiota data (n=18 340) obtained from a meta-analysis of a large-scale multi-ethnic genome-wide association study was used as exposure data. The analysis primarily employed the inverse variance weighting method, assessing the results based on the odds ratio (OR) and 95% confidence interval (CI). Quality control was conducted using leave-one-out analysis, heterogeneity tests, and the MR-PRESSO method. Results An increased abundance of the genus Oscillibacter was associated with a higher probability of developing HCC (OR=1.411, 95% CI: 1.049-1.899, P=0.025). Leave-one-out analysis indicated that the study results were stable and no instrumental variables had a strong impact on the results. This showed a positive causal relationship between gut microbiota and HCC, which could eliminate the effects of heterogeneity and horizontal gene pleiotropy on causal effect estimation. Conclusion An increased abundance of the genus Oscillibacter may raise the probability of developing HCC.
Authors and Affiliations
CHEN Yuyan, REN Haozhen, GUAN Wenxian
Keywords
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- EP ID EP738395
- DOI 10.13429/j.cnki.cjcr.2024.06.015
- Views 33
- Downloads 0
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