RELATIONSHIP OF HEPATIC AND RENAL DYSFUNCTION WITH HAEMORRHEOLOGICAL PARAMETERS IN PLASMODIUM FALCIPARUM MALARIA
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2015, Vol 2, Issue 18
Abstract
The clinical pattern of malaria has changed worldwide including India in last decade. Earlier cerebral malaria was the predominant manifestation of severe malaria, whereas now the combination of jaundice and renal failure are more common. Severe haemorrhage is seen in upto 5% of patients with severe malaria. Studies on renal and hepatic dysfunction in Plasmodium falciparum malaria are a plenty, but there is a paucity of studies correlating haemorrheological abnormalities with hepatic and renal dysfunction in Plasmodium falciparum malaria. METHODS: 100 patients of malaria with positive peripheral blood smear for plasmodium falciparum, out of which 50 cases with AKI and Hepatic failure during the period January 2012- June 2013. In department of general medicine, Government General Hospital, Kakinada. GROUP A: Comprising 50 consecutive adult patients of all age groups and both genders who had jaundice or renal failure or both at the time of admission. GROUP B: comprising 50 consecutive cases of plasmodium falciparum malaria and had no complications. RESULTS: In group A patients all parameters are significantly raised as compared to group B patients. CONCLUSION: 10% of patients had clinically overt bleeding manifestations, this indicates subclinical haemorrheological dysfunction in patients suffering from falciparum malaria with hepatic and renal dysfunction, high incidence of subclinical DIC, evidenced by prolonged aPTT (56%), low total platelet count (58%), and PT (20%). An observational, screening, analytical prospective study. 100 cases of PF positive complicated and uncomplicated cases during the period - January 2012- June 2013.
Authors and Affiliations
Valluri Satya Prasad, Manavalla Subrahmanyam
Keywords
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- EP ID EP227396
- DOI 10.18410/jebmh/2015/393
- Views 72
- Downloads 0
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