Relationship of Serum HbA1c and Fasting Serum Lipids with Central Macular Thickness in Patients with Type 2 Diabetes Mellitus
Journal Title: Journal of Clinical Research and Ophthalmology - Year 2016, Vol 3, Issue 2
Abstract
Background: Diabetic retinopathy, the most common retinal vascular disease, is the leading cause of new-blindness in adults during the third through sixth decades of life. Purpose: To determine the correlation between central macular thickness (CMT) and both HbA1c and fasting serum lipids level in early stage non proliferative diabetic retinopathy. Results: The patients were divided into two groups as HbA1c >8.67% (Group I, n: 60) and HbA1c ≤8.67% (Group II, n: 72). The mean CMT of better eyes was 273.28±34.61 µm. The mean CMT of worse eye was 304.40±64.31 µm. According to comparison between Group I (HbA1c >8.67%) and Group II (HbA1c ≤8.67%) the mean CMT’s were not different in two groups (P: 0.37). Main findings: HbA1c level (8.76%) were significantly higher than normal upper limits in patient even under diabetic medication. In further analyses the mean CMT’s was not different in worse eye in Group I and Group II and it was not significantly different in better eyes in these two group either. Conclusion: Even we did not observed any correlation between level of HbA1c and the degree of CMT statistically in either worse or better eye, result of our study showed that patient had increased macular thickness even early stage of NPDR while having significantly higher HbA1c even under systemic medication. Brief Summary: The purpose of the current study was to determine the correlation between diabetic macular edema and both HbA1c and fasting serum lipids in early stage non proliferative diabetic retinopathy. We did not observed any correlation between level of HbA1c and the degree of central macular thickness (CMT) statistically in either worse or better eye. Our results may indirectly evidence of insufficient metabolic treatment can cause macular edema prior to other retinal signs. Potential implications: Systemic risk factor for follow-up of macular edema secondary to diabetes mellitus.
Authors and Affiliations
Ayse Gul Kocak Altintas, Mehmet Citirik, Bayram Gulpamuk
Keywords
Related Articles
- EP ID EP231160
- DOI 10.17352/2455-1414.000031
- Views 80
- Downloads 0
A Rare Case of Benign Intracranial Hypertension with Bilateral Complete Visual Loss and Sixth Nerve Paresis
Introduction: Benign intracranial hypertension (BIH) is a disorder defined by symptoms and signs suggestive of increased intracranial pressure (ICP) in the absence of any cause evident on neuroimaging or other evaluation...
Bilateral Numerous Warts in Upper and Lower Eyelids, in Middle-Aged Man
Background: Warts are small, usually painless growths on the skin caused by a virus called human papillomavirus (HPV). Most, but not all, are generally harmless [1,2]. Warts can be disfiguring and embarrassing. Sometime...
Posterior Polar Hemispheric Choroidal Dystrophy
The term “posterior polar hemispheric choroidal dystrophy” was first used by Yannuzzi to describe the annular, hemispheric loss of retinal pigment epithelium and choriocapillaris [1]. Since then, there have been no furth...
Cutaneous Horn of the Eyelid: Anatomoclinical Implications
Cutaneous horns are relatively rare benign tumors which occur most frequently on sun exposed skin and develop on various types of underlying skin lesions: benign, premalignant and malignant. The treatment of choice consi...
Valacyclovir as a Therapeutic Agent in Acute Retinal Necrosis: Two Case Reports
Introduction: Acute retinal necrosis (ARN) is a rare, rapidly progressive viral retinitis. The current standard of care for ARN consists of intravenous acyclovir for 5-10 days, followed by oral acyclovir for an additiona...