Relevance of platelet indices in predicting prothrombotic activity in type 2 diabetes mellitus in correlation with HbA1C
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
Context: Diabetes mellitus is a chronic metabolic syndrome. Recently, a prothrombotic state, characterized by abnormalities in platelet function has been recognized as a component of metabolic syndrome. The increased platelet activity may play a role in the development of vascular complications of this metabolic disorder. The mean platelet volume (MPV) is an indicator of the average size and activity of platelets. Aims: To compare platelet indices between type 2 diabetic patients and control group, to analyse the correlations between MPV and FBG, PBG in diabetic patients, to evaluate MPV according to HbA1C levels in diabetic group. Materials and Methods: Platelet counts and MPV were measured in 300 Type 2 diabetic patients and 300 nondiabetic subjects using an automated blood cell counter. The blood glucose levels and HbA1c levels were also measured. Statistical evaluation was performed by SPSS using Student’s t test and Pearson correlation tests. Results: the mean platelet counts and MPV were higher in diabetics compared to the nondiabetic subjects [277.46 ± 81 X 109/l vs. 269.79 ± 78 X 109/l (P= 0.256)], 8.29±0.735 fl versus 7.47±0.73 fl (P= 0.001), respectively. MPV showed a strong positive correlation with fasting blood glucose, and HbA1C levels (P=0.001). Conclusions: This study showed that, Mean platelet volume is increased in diabetic patients than in healthy controls. MPV is positively correlated / associated with glycemic control ( FBG,HbA1C). MPV significantly increased in diabetics with HbA1C more than 7% than those with less than 7%. In diabetes mellitus, MPV is increased and it is indicative of worsening glycemic control.
Authors and Affiliations
Dr. Murari. Apuroopa, Dr. N Sruthi, Dr. D. Naveen Chandra Rao, Dr. D. Gayathri, Dr. M. Prasanthi, Dr. D. Ranga rao
Keywords
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