Renal Angiomyolipoma: A Clinicopathological Study of Seven Cases and Review of the Literature
Journal Title: The Bulletin of Urooncology - Year 2020, Vol 19, Issue 3
Abstract
Objective: Renal angiomyolipomas (AMLs) are mesenchymal kidney tumours that have triphasic histology. This study aimed to present the clinical, pathological and immunohistochemical features of seven AML cases along with a review of the relevant literature. Materials and Methods: Seven cases of pathologically diagnosed AML were included in the study. The presence of fat tissues, smooth muscle cells, blood vessels and epithelioid components were determined for all cases. Tumour necrosis, haemorrhage, mitosis, lymphovascular and perineural invasion were also recorded. Immune markers [human melanoma black-45 (HMB45), Melan-A, smooth muscle actin (SMA), cytokeratin], previously applied to the tissue sections, were re-evaluated as positive and negative staining. Results: All cases were classic AML types. Five patients had flank pain and two had haematuria. The tumour was located in the left kidney in two cases and in the right kidney in five cases. The mean size of the AMLs was 7.36±4.23 cm. Tumours were separated from the normal kidney parenchyma with good margins and composed of mature fatty tissues, blood vessels and fusiform spindle smooth muscle cells in varying proportions. Immunohistochemically, all cases were positive with HMB-45, Melan-A and SMA. No case was positive for cytokeratin staining. Conclusion: Correct histological diagnosis of renal AML subtypes is crucial. Incorrect diagnosis of classic renal AML may lead to inadequate postoperative management. Clinicians should be aware of the malignant potential of epithelioid AML and the need for long-term follow-up.
Authors and Affiliations
Didar Gürsoy, İlke Evrim Seçinti, Sibel Hakverdi, Sadık Görür
Keywords
Related Articles
- EP ID EP688787
- DOI 10.4274/uob.galenos.2020.1438
- Views 148
- Downloads 0
“Atypical Cell’’ Parameter in Automated Urine Analysis for the Diagnosis of Bladder Cancer: A Retrospective Pilot Study
Objective: To evaluate the application of an automated urine analyzer (AUA) for the diagnosis of bladder cancer (BC). Materials and Methods: A retrospective data analysis of 2365 urine specimens from the department of u...
Laparoscopic Partial Nephrectomy: Tips and Tricks
No summary
Preoperative and Postoperative Gleason Score Correlation of Patients Who Underwent Radical Prostatectomy
Objective: We aimed to report the consistency between transrectal needle biopsy (TRNB) Gleason scores (GSs) and prostatectomy specimen GSs based on upgrading and downgrading rates. Materials and Methods: Data of patient...
What is the Prostate Specific Antigen Cut-off Value to Detect Metastases in Ga-68 Prostate Specific Membrane Antigen Ligand Positron Emission Tomography/ Computer Tomography Imaging for Intermediate and High-risk Prostate Cancer?
Objective: The aim of this study was to detect a prostate specific antigen (PSA) cut-off value for metastases, and prevent unnecessary use of Ga-68 prostate specific membrane antigen (PSMA) ligand positron emission tomog...
The Effect of Framingham Score on the Oncological Outcomes in Localized (T1-T2 Stage) Renal Cell Carcinoma Patients
Objective: To evaluate the effect of cardiovascular disease risk on local recurrence, distant metastasis development and cancer-specific survival in patients with localized (stage 1 and 2) renal cell carcinoma (RCC). Ma...