Renal resistive index and its association with insulin resistance in patients with Type 2 Diabetes mellitus
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 4
Abstract
Background: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD) and a major cause of cardiovascular mortality. Aim: The aim of this study is to assess the significance between renal resistive index with albumin creatinine ratio and to explore possible correlation with HbA1c, homeostasis model assessment-estimated insulin resistance (HOMA-IR) in type 2 diabetic patients. Materials and methods: Sixty type 2 diabetic patients with more than 5 year diabetic duration in the age group of 35 to 60 years were selected for this study and 30 age matched healthy individuals were selected as control group. The renal Doppler studies were performed using a low-frequency ultrasound transducer and a standardized diagnostic scanning protocol for image acquisition. Glycated hemoglobin (HbA1C), Insulin, microalbumin were analyzed by conventional standardized methods. Results: Interlobar and Arcuate artery Renal resistive index values were significantly increased in diabetic patients compared with controls and also significantly increased values were observed in microalbuminuric diabetics compared with normoalbuminuric diabetics. The Interlobar artery resistive index levels were positively correlated with the albumin creatinine ratio (ACR), glycated hemoglobin (HbA1C) and insulin resistance. Conclusion: RRI might be a non invasive diagnostic marker of early renal vascular changes and is positively correlated with insulin resistance and HbA1c in type 2 diabetes mellitus.
Authors and Affiliations
Santha . K, Balu Mahendran . K, Perumal . K. K, Inmozhi . R, Sethupathy . S
Keywords
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- EP ID EP593721
- DOI 10.9790/0853-1604035157.
- Views 76
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