Renin-angiotensin-aldosterone system in bodybuilders using supraphysiological doses of anabolic-androgenic steroids
Journal Title: Biology of Sport - Year 2011, Vol 28, Issue 1
Abstract
This study was carried out in 40 bodybuilders voluntarily taking supraphysiological doses of anabolic-androgenic steroids (AAS). Echocardiographic examination of the heart and blood analysis were performed, and concentration of AAS in urine was examined. The presence, or absence, of AAS in urine had no influence on the echocardiographic parameters of the heart, body mass, body mass index (BMI) and aldosterone level in blood plasma. It seems, therefore, that the presence of AAS in urine may confirm heart hypertrophy and overuse of AAS, while the absence of AAS in urine does not exclude the cardiological changes occurring as a result of taking the drugs. Metabolites detected in urine showed that the intake of 17α-alkyl testosterone derivatives caused higher values of left ventricular mass and BMI. However, the level of HDL cholesterol was lower in bodybuilders using only 19-nor-testosterone. Elevated level of plasma aldosterone did not differ between the two groups. As could be expected, the highest level of AAS in urine was detected in bodybuilders currently self-administering the anabolic-androgenic steroids (on cycle). The level of AAS in the urine decreased after stopping taking the drugs (off cycle). Refraining from AAS abuse for a period of 1-2 years was associated with a significant decrease in aldosterone level in the plasma. The positive correlations found between the blood plasma aldosterone, left ventricular mass and BMI lead to the conclusion that large doses of AAS taken by bodybuilders would cause extra activation of the renin-angiotensin-aldosterone system.
Authors and Affiliations
K Chrostowski, D Kwiatkowska, A Pokrywka, B Wójcikowska-Wójcik, R Grucza
Keywords
Related Articles
- EP ID EP59035
- DOI -
- Views 103
- Downloads 0
Landing errors in the men’s floor exercise are caused by flight characteristics
Landing errors on men’s floor exercises are caused by the flight parameters. Depending of the flight phase is determined the magnitude of the landing mistake. On the sample of all gymnasts (n=97) who were competing in th...
Dynamic analysis of rowing on Concept II type C ergometer
The purposes of this study were to: a) determine the potential of rowers’ strength and the degree of its utilization during rowing, b) provide a quantitative description of the rowing technique. The crews of two quadrupl...
Comparison of techniques for the measurement of skin temperature during exercise in a hot, humid environment
Exercising or working in a hot, humid environment can results in the onset of heat-related illness when an individual’s temperature is not carefully monitored. The purpose of the present study was to compare three techni...
The angiotensin converting enzyme gene i/d polymorphism in ellite polish and lithuanian judo players
A common polymorphism in the angiotensin converting enzyme I gene (the ACE I/D variant) represents one of the first characterized and the most widely studied genetic variants in the context of elite athletes status and p...
Comparison of DeLorme with Oxford resistance training techniques: effects of training on muscle damage markers
Aim: The purpose of this study was comparing DeLorme with Oxford methods through ten repetition maximum (10 RM) performance and serum creatine kinase (CK) and lactate dehydrogenase (LDH) activity. Methods: Before and aft...