Reproducibility of Modified Gleason Scoring System and Grade Group in Prostate Carcinoma on Microphotographs
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2017, Vol 6, Issue 4
Abstract
Background: Pathologists can quickly transmit the microscopic images photographed in a certain location to remote centers for analyzing the images. Gleason scoring system forms an important prognostic parameter for therapeutic decision and in the overall management of prostate cancer patients. Aims: 1. To study various histopathological patterns of prostatic carcinoma. 2. To evaluate the reproducibility of modified Gleason scoring system and Grade group in prostate carcinoma on microphotographs. Material and Methods: A retrospective study of invasive prostate cancer cases was conducted from January 2014 to October 2016. It was an analytical type of study at a rural tertiary care institute. Histopathology slides of prostate adenocarcinoma slides were retrieved, reviewed, scored and graded according to World Health Organization [WHO] 2016. The representative images captured by 13 megapixel mobile camera were sent to two pathologists by Email and were evaluated separately. The primary Gleason pattern, secondary Gleason pattern, total Gleason score and Grade groups were documented. Concordance and kappa statistics was applied. Results: Twelve cases were analyzed. Concordance was better in secondary Gleason pattern when compared with primary Gleason pattern, total Gleason score and Grade group. The present study showed substantial agreement in primary Gleason pattern; and substantial to almost perfect agreement in secondary Gleason pattern, Gleason total score and grade group. The overall performance of both the pathologists was satisfactory. Conclusions: Modified Gleason scoring system and grade group has good reproducibility in prostate carcinoma on microphotographs. The analysis of representative images is a feasible and time saving exercise.
Authors and Affiliations
Anupama M.
Keywords
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- EP ID EP471601
- DOI 10.21088/ijprp.2278.148X.6417.39
- Views 85
- Downloads 0
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