Rescue effects of aqueous seed extracts of Foeniculum vulgare and Carum carvi against cadmium-induced hepatic, renal and gonadal damage in female albino rats
Journal Title: Asian Pacific Journal of Tropical Medicine - Year 2017, Vol 10, Issue 12
Abstract
Objective: To investigate the protective effects of aqueous seed extracts of fennel “Foeniculum vulgare” (FVE) and caraway “Carum carvi” (CCE) on liver, kidney and reproductive organs in female rats against cadmium chloride (CC) intoxication. Methods: A total of 36 adult female rats were divided into six groups, six in each group. Control group (fed normal diet), CC-treated group (50 mg CC/kg diet), CCE-treated group (150 mg CCE/kg diet), CCE + CC group, FVE (150 mg/kg diet) and FVE + CC. One month later, all rats were sacrificed and all samples were collected at proestrus phase. Results: The toxic effects of CC were confirmed biochemically by significant increase of serum concentration of liver enzymes (P < 0.05), and creatinine (P < 0.001). Moreover, CC increased significantly the serum level of malondialdehyde (MDA) and decreased the total antioxidant capacity (TAC) (P < 0.001). In addition, serum concentrations of estrogen, progesterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were significantly decreased (P < 0.01). Histopathologically, CC-treated group revealed marked pathological changes in renal, hepatic, ovarian and uterine tissues. All toxic findings observed in liver and kidney with CC treatment were found to be ameliorated markedly after co-treatments with FVE or CCE. Furthermore, co-treatment of FVE with CC improved significantly all studied reproductive parameters (P < 0.01). Conclusions: Both FVE and CCE could be used as efficient treatments for liver and kidney against CC intoxication. Moreover, FVE could be utilized as a potent treatment to protect and improve female fertility from cadmium intoxication.
Authors and Affiliations
Ahmed Abdel-Wahab
Keywords
Related Articles
- EP ID EP250419
- DOI 10.1016/j.apjtm.2017.10.019
- Views 123
- Downloads 0
Synergistic renoprotective effect of a compiled branched-chain amino acids and Cymbopogon schoenanthus extract against experimentally induced oxido-nitrosative renal insult
Objective: To better investigate the protective role of branched-chain amino acids (BCAAs) and Cymbopogon schoenanthus (CS) extract against the potassium dichromate (PDC)-induced oxido-nitrosative nephrotoxic insult in t...
In vitro and in vivo investigation of natural compounds from seed extract of Mucuna pruriens lacking L-DOPA for the treatment of erectile dysfunction
Objective: To investigate the biological effects of the Mucuna pruriens (M. pruriens) seed extracts that lacked L-DOPA, which was formerly reported as the active ingredient, on erectile dysfunction (ED) both in vitro and...
miR-21 targets and inhibits tumor suppressor gene PTEN to promote prostate cancer cell proliferation and invasion: An experimental study
Objective: To study whether miR-21 targets and inhibits tumor suppressor gene PTEN can promote prostate cancer cell proliferation and invasion. Methods: Prostate cancer cell lines PC-3 were cultured and divided into nega...
Effects of Di-(2-ethylhexyl) phthalate on thyroid in pubertal female rats and related mechanism
Objective: The quality of the tropical environment is directly related to the sustainable development of the economy, society and the health of people in the tropics. Di-(2-ethylhexyl) phthalate (DEHP) is a common plasti...
Helianthus tuberosus (Jerusalem artichoke) tubers improve glucose tolerance and hepatic lipid profile in rats fed a high-fat diet
Objectives: To analyze the effects of feeding Helianthus tuberosus (HT) tubers on glucose tolerance and lipid profile in rats fed a high-fat diet (HFD). Methods: A normal HFD or HFD including 10 w/w% HT tubers (HFD + HT)...