Research progress of optic nerve regeneration
Journal Title: Eye Science (Yanke Xuebao) - Year 2022, Vol 37, Issue 1
Abstract
Optic nerves are a part of the central nervous system, which is difficult to regenerate after injury. Optic nerve injury is usually accompanied by continuous apoptosis of retinal ganglion cells (RGCs) and degeneration or necrosis of optic nerves, resulting in visual impairment or even complete blindness. At present, the basic research on optic nerve regeneration mainly focuses on protecting and maintaining the survival of RGCs after optic nerve injury, promoting RGCs axon regeneration, and reconstructing optic nerve function. In this paper, RGCs protection, axon regeneration, and optic nerve function reconstruction are used as key words to collect the latest domestic and foreign literatures on optic nerve regeneration. The research progress of optic nerve regeneration in recent years was reviewed from the aspects of antioxidant stress, provision of exogenous cytokines, inflammatory stimulation, anti-glial scar, gene regulation and so on, in order to help the follow-up basic research and clinical translation.
Authors and Affiliations
Tonghe PAN, Yate HUANG, Kaihui NAN
Keywords
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- EP ID EP763616
- DOI 10.3978/j.issn.1000-4432.2021.09.02
- Views 12
- Downloads 0
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