Research progress of oxidative stress in sepsis-associated liver injury
Journal Title: Perioperative Precision Medicine - Year 2024, Vol 2, Issue 1
Abstract
Sepsis is a systemic inflammatory response that caused by infection or trauma, often resulting in multiple organ dysfunction. Its mortality rate is relatively high, ranging between 54% and 68%, and ineffective treatment and poor prognosis pose significant challenges to healthcare in recent years. One of the main pathogeneses of sepsis-induced liver injury is oxidative stress (OS), which refers to a state where the antioxidant system cannot balance oxidative products, leading to the accumulation of excessive oxidative products in the body. When sepsis occurs, the amount of reactive oxygen species produced by the body increases far beyond the levels that can be scavenged by the antioxidant system, thus damaging liver cells and aggravating liver damage. This article introduces the oxidative/antioxidant system, oxidative stress-related pathways, and the molecular mechanism of OS in various types of hepatocytes, with emphasis on the antioxidant treatment on different hepatocytes, in order to understand the mechanism of OS involved in the development and progression of sepsis-associated liver injury. As the research deepens, improving liver function through the treatment of different cells and facilitating related clinical research are expected to provide a new target pathway for the treatment of sepsis-associated liver injury.
Authors and Affiliations
Hui Su,Tianying Xu, Renke Sun, Yu Xiang, Yangmengna Gao, Kecheng Zai, Shangping Fang
Keywords
Related Articles
- EP ID EP749972
- DOI 10.61189/270899wnwlnz
- Views 62
- Downloads 0
Difficult airway management in patients with laryngeal tumor: Case series and systematic review
Airway management in patients with laryngeal tumor presents significant challenges and risks. SEEKflex (Safe Easy Endotracheal Kit-flexible) is a modified introducer developed by our team for the intubation in severe COV...
Research advances in understanding the role and mechanism of pyroptosis in myocardial ischemia-reperfusion injury
Myocardial ischemia-reperfusion injury (MIRI) emerges when the restoration of blood flow fails to recover myocardial function following transient ischemia, marking a significant pathological challenge that adversely affe...
The effectiveness of a novel modified retracting arm for transaxillary endoscopic thyroid surgery to minimize complications: A randomized controlled study
Objective: To evaluate the safety of a novel modified retracting arm for endoscopic thyroidectomy by gasless unilateral axillary approach (ETGUA) and its effectiveness in minimizing complications. Methods: A novel retrac...
Research progress of frontier image processing in medical endoscopes
In the modern medical diagnosis, digital medical images can provide physicians with a more accurate, visualized, and three-dimensional view of various tissues. These images assist in predicting, diagnosing, and treating...
Perioperative care in hypoadrenalism: A narrative review
Impaired production of adrenal hormones or hypoadrenalism is not uncommon and has various aetiologies. Untreated hypoadrenalism during operative period can lead to preventable major adverse events. Identification and ris...