Research progress on the function and metabolism of d-alanine in bacteria
Journal Title: 口腔疾病防治 - Year 2019, Vol 27, Issue 4
Abstract
D-alanine is a chiral molecule of L-alanine that participates in the formation and regulation of cell wall peptidoglycans, phosphoteichoic acid, spore germination and respiratory metabolism in individual bacteria. D-alanine participates in the formation and regulation of biofilm in bacterial communities. The function and metabolism of D-alanine in bacteria are specific, and the enzymes and genes in its metabolic pathway can be used as drug targeting sites. In this paper, the synthesis, metabolism and function of D-alanine in bacteria were reviewed, and the relationship between D-alanine and pathogenicity of Streptococcus mutans was discussed to provide a theoretical basis for candidate targeting sites of anti-caries drugs. According to existing research results, the enzymes and related genes involved in D-alanine metabolism play important roles in the growth and biofilm formation of Streptococcus mutans, and D-alanine is expected to be a target for the design of anti-caries drugs.
Authors and Affiliations
GUO Xiao, DU Xinmei, CHENG Lei, ZHOU Xuedong, LI Mingyun
Keywords
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- EP ID EP662891
- DOI 10.12016/j.issn.2096-1456.2019.04.012
- Views 185
- Downloads 0
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