Researches of the assortment of drugs for the treatment of diabetes II type оn the pharmaceutical market of Ukraine

Journal Title: Фармацевтичний журнал - Year 2019, Vol 2, Issue 2

Abstract

Type II diabetes is a global pandemic, as evidenced by data from a study by the International Diabetes Federation. The disease is a chronic, progressive process with a special metabolic condition that is characterized by hyperglycemia. Therapeutic effects should be aimed at eliminating the main causes of type II diabetes mellitus: insulin secretion dysfunction, a decrease in tissue resistance to insulin, or a combination of these. The aim of the work was to study the range of oral antidiabetic drugs on the pharmaceutical market of Ukraine for the treatment of type II diabetes. The objects of study were drugs used in the treatment of type II diabetes. Studies were conducted using content analysis of official sources of information. In the course of the work, the range of antidiabetic drugs, classification, mechanism of action, cost, main advantages and disadvantages of use were established. It is established that the most common dosage form for the treatment of diabetes are tablets, which occupy more than 90% of the total range of drugs. The lack of modern types of dosage forms in the group A10B is the basis for the creation of new drugs with improved biopharmaceutical and consumer properties. The data obtained indicate a strong dependence of the pharmaceutical market of antidiabetic drugs of Ukraine on imports, with the exception of insulin (А10В). The share of imports in the market in quantitative terms for the period under review amounted to more than 75.86% of the total market volume. It has been established that the use of drugs of the A10B A, A10B F groups with an affordable cost with active therapy contributes to a lower rate of development of diabetes mellitus type II and a high degree of regression to normal glucose, without affecting the fluctuations in body weight. Preparations of the new generation (A10B H, A10B J, A10B X) are highly effective with an insufficient safety profile. The high cost of drugs of these groups makes them inaccessible to the general population. It has been shown that only metformin and voglibosis have a positive effect on body mass fluctuation rates, which will ensure safe and effective glycemic control with minimal risk of hypoglycemia and without weight gain in the treatment of type II diabetes.

Authors and Affiliations

І. V. Kovalevska, O. A. Ruban, O. M. Yevtushenko

Keywords

Related Articles

The analysis modern trends of social and effective organization of pharmaceutical provision to rural population in Ukraine

In Ukraine, the pharmaceutical provision of the rural population, which is about 31% in the total population of the country, requires a qualitatively new approaches taking into account the social orientation of the pharm...

Comorbidity aspects of pharmacotherapy of the addictive dependence

Important problems of modern clinical medicine and pharmacy act comorbidity and polymorbidity caused by the anatomical proximity of affected organs, a common pathogenesis causation or a random combination of diseases. Th...

Study of ointment base influence over biopharmaceutical characteristics of praziquantel semisolid dosage form for external use

Problem of acne dermatosis, complicated with demodicosis pharmacotherapy is one of the topical for the domestic dermatology because of a number of antidemodicosis medications isn’t large and almost all of the most effect...

Pharmaceutical aspects of photometric analysis of drugs

Problems of improving ways to assess the quality of medicines currently apply to all sections of the pharmacopoeia analysis, due to the revision of traditional approaches to identifying, testing for purity, the determina...

HPLC-determination of active components in dietary supplement «L-CARNITINE smart»

Dietary supplements are compositions of biologically active substances intended for consumption with food or addition to food products for the purpose of optimization of metabolic processes and functions of the human bod...

Download PDF file
  • EP ID EP559234
  • DOI 10.32352/0367-3057.2.19.02
  • Views 64
  • Downloads 0

How To Cite

І. V. Kovalevska, O. A. Ruban, O. M. Yevtushenko (2019). Researches of the assortment of drugs for the treatment of diabetes II type оn the pharmaceutical market of Ukraine. Фармацевтичний журнал, 2(2), 13-23. https://europub.co.uk./articles/-A-559234