Researches of the assortment of drugs for the treatment of diabetes II type оn the pharmaceutical market of Ukraine
Journal Title: Фармацевтичний журнал - Year 2019, Vol 2, Issue 2
Abstract
Type II diabetes is a global pandemic, as evidenced by data from a study by the International Diabetes Federation. The disease is a chronic, progressive process with a special metabolic condition that is characterized by hyperglycemia. Therapeutic effects should be aimed at eliminating the main causes of type II diabetes mellitus: insulin secretion dysfunction, a decrease in tissue resistance to insulin, or a combination of these. The aim of the work was to study the range of oral antidiabetic drugs on the pharmaceutical market of Ukraine for the treatment of type II diabetes. The objects of study were drugs used in the treatment of type II diabetes. Studies were conducted using content analysis of official sources of information. In the course of the work, the range of antidiabetic drugs, classification, mechanism of action, cost, main advantages and disadvantages of use were established. It is established that the most common dosage form for the treatment of diabetes are tablets, which occupy more than 90% of the total range of drugs. The lack of modern types of dosage forms in the group A10B is the basis for the creation of new drugs with improved biopharmaceutical and consumer properties. The data obtained indicate a strong dependence of the pharmaceutical market of antidiabetic drugs of Ukraine on imports, with the exception of insulin (А10В). The share of imports in the market in quantitative terms for the period under review amounted to more than 75.86% of the total market volume. It has been established that the use of drugs of the A10B A, A10B F groups with an affordable cost with active therapy contributes to a lower rate of development of diabetes mellitus type II and a high degree of regression to normal glucose, without affecting the fluctuations in body weight. Preparations of the new generation (A10B H, A10B J, A10B X) are highly effective with an insufficient safety profile. The high cost of drugs of these groups makes them inaccessible to the general population. It has been shown that only metformin and voglibosis have a positive effect on body mass fluctuation rates, which will ensure safe and effective glycemic control with minimal risk of hypoglycemia and without weight gain in the treatment of type II diabetes.
Authors and Affiliations
І. V. Kovalevska, O. A. Ruban, O. M. Yevtushenko
Keywords
Related Articles
- EP ID EP559234
- DOI 10.32352/0367-3057.2.19.02
- Views 54
- Downloads 0
Application of surface in physics methods in pharmaceutical development of the medicine on the basis of essential phospholipids
The main issues addressed in the process of pharmaceutical medicine’s development include the choice of substance, excipients; development of technological and analytical methods of control; definition of critical points...
Spectral characteristics and electronic structures of synthetic derivatives of coumarin. P a r t III. Pharmacophore and chemical-pharmacology structure of bicoumarin and ethylbiscoumacetas (neodicoumarine)
Most widely used in clinical practice enteral anticoagulants among which common dicoumarin and ehtilbiscoumacetas (neodicoumarin) are the structural derivatives of 4-hydroxycoumarin – compounds isolated from sweet clover...
Forensic and pharmaceutical study of abuse and developing the principles of reducing the demand for psychoactive substances of different classification and regulatory groups
The article by forensic pharmaceutical study found that illicit substance abuse of different classification and regulatory groups is one of the most difficult problems of today, which is acute to provided the countries o...
Testing of the mutagenic potential of N-(γ-aminobuturyl)-1-aza-15-crown-5 hydrochloride in Ames test microplate modification
In recent years, studies in the field of chemical mutagenesis have undergone significant development, due to the introduction of a large number of different chemicals and scientific advances in the creation and use of ne...
Antioxidant properties of hidazepam and amitriptyline with pain syndrome of rats
Peroxide modification of cell biostructures and functions due to the activation of free radical oxidative processes underlies the pathogenesis of a significant number of diseases different in its etiology. The ability of...