Resistotypes of Rhodococcus equi isolated from foals with respiratory problems
Journal Title: Journal of Experimental Biology and Agricultural Sciences - Year 2016, Vol 4, Issue 3
Abstract
Rhodococcus equi has been recognized primarily as a respiratory pathogen of equines particularly of foals between one and four months of age. R. equi is ranked among the most important disease problems in equines especially because of its high prevalence and mortality rate. R. equi being an intracellular pathogen is very fastidious and requires prolonged specific antibiotic combination therapy lasting up to three months for successful treatment. This assumes further importance as no effective vaccination is available for prevention. It has zoonotic potential and may be responsible for infection in immunocompromised humans. This study is aimed at analyzing the distribution pattern of the resistotypes (R-types) of various isolates of R. equi in different areas of Haryana and Rajasthan, India. Antimicrobial susceptibility pattern of R. equi isolates was determined by Kirby Bauer disc diffusion method following the Clinical and Laboratory Standards Institute (CLSI) guidelines. A total of twenty eight clinical isolates of R. equi from foals from different parts of Haryana and Rajasthan were used in this study. Antibiogram of R. equi isolates with 33 antibiotics revealed ten distinct R-types: R-type 1 to R-type 10, on the basis of variable results of four antibiotics i.e. amoxycillin, gentamycin, colistin and streptomycin. Out of ten resistotypes obtained the relative frequencies of R-1 resistotype and R-4 resistotype were found to be high i.e. 28.57% and 25%, respectively. Differentiation of R. equi strains into R-types is an important tool for therapeutics. In addition to direct foal management, it may have implication in identifying the source and spread of infection, and as epidemiological marker to correlate various isolates from various places, ultimately helping in therapeutics for timely control.
Authors and Affiliations
Sourabh Chhabra, S K Khurana, P K Kapoor, Richa Khirbat
Keywords
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- EP ID EP428100
- DOI 10.18006/2016.4(3S).242.248
- Views 69
- Downloads 0
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