Results of Transcranial Doppler in Children with Sickle Cell Disease: Correlation between the Time-Averaged Mean of Maximum Velocity and Some Hematological Characteristics
Journal Title: Iranian Journal of Blood and Cancer - Year 2012, Vol 5, Issue 1
Abstract
Abstract Background: Transcranial Doppler ultrasonography results have not been previously studied in among Iranian sickle cell anemia patients. The present study was performed to evaluate the pattern of intracranial flow velocities among Iranian children with sickle cell anemia and the hematological parameters that can affect the time-averaged mean of maximum velocity in major intracranial arteries. Materials and methods: A total of 34 patients with sickle cell anemia aged 2-16 years (Mean: 9.5 ±4.1 years) were enrolled in this cross sectional study. A special pediatric Doppler transducer was used to study intracranial vessels such as left and right middle cerebral arteries and the time-averaged mean maximum velocity was determined for major intracranial arteries on each side. The results of transcranial Doppler were studied according to the Stroke Prevention Trial in Sickle Cell Anemia criteria. Results: In total a relatively high transcranial Doppler value was found in 9 patients (26.4%) on either right or left side. Out of these 5 patients (14.7%) were in low risk zone (140-169 cm/sec), 3 patients (8.8%) in conditional zone (170 to 200 cm/sec), and one patient (2.9%) in high risk zone (>200cm/sec). Time averaged mean of maximum velocity on the right side and the left side had inversely significant correlation with Hb F (p=0.03) and Hb S (p=0.02). Conclusion: Transcranial Doppler parameters in patients with sickle cell anemia in our study indicated about one forth of patients to have degrees of increased intracranial flow velocity. In contrast to most other studies the cerebral blood flow velocities among our patients were not significantly correlated with most haematological parameters except for Hb F and Hb S. Key Words: Sickle cell anemia, transcranial, Doppler, children, Iran.
Authors and Affiliations
B. Keikhaei, H. Mousakhani, M. Oghbaee
Keywords
Related Articles
- EP ID EP366204
- DOI -
- Views 79
- Downloads 0
Metronomic Maintenance Therapy in Refractory Acute Myeloblastic Leukemia with Monosomy 7
Patients with acute myeloblastic leukemia (AML) with monosomy 7 are a group of patients with refractory AML who have a very poor prognosis. Therefore, rationally designed new therapies, including metronomic chemotherapy...
Flow Cytometric Measurement of CD41/CD61, CD42b Platelet Receptors and Platelet Factor 3 Activity in Lyophilized Infusible Platelet Membrane Preparation
Background: The short life time of human platelet units has led to a chronic shortage of fresh platelets in blood transfusion centers. Many approaches have been investigated experimentally to produce new hemostatically a...
Incidence and Pattern of Childhood Leukaemia in Basrah, Iraq during 2003-2007
Background: Environment of Basrah is seriously contaminated with chemical leukomogens as a result of recent military conflicts. Many studies in the past few years have reported an increase in the incidence of leukemia in...
Evaluation of Anthracycline Effects on NT-ProBNP Plasma Level in Children with Malignancy
Background: NT-proBNP is a marker that is released from ventricles in response to pressure and volume overload. Raised plasma level of NT-proBNP is seen in ventricular dysfunction, ventricular muscular mass reduction or...
Breast Cancer Associated with Dermatomyositis
Dermatomyositis (DM) is a rare idiopathic inflammatory myopathy with characteristic skin lesions. Case series have shown an association between dermatomyositis and malignancy. Malignancy has been found in 15-25% of the a...