Resurgence of pertussis at the age of vaccination: clinical, epidemiological, and molecular aspects
Journal Title: Jornal de Pediatria - Year 2015, Vol 91, Issue 4
Abstract
Objective Report the incidence, epidemiology, clinical features, death, and vaccination status of patients with whooping cough and perform genotypic characterization of isolates of B. pertussis identified in the state of Paraná, during January 2007 to December 2013. Methods Cross-sectional study including 1,209 patients with pertussis. Data were obtained through the Notifiable Diseases Information System (Sistema de Informação de Agravos de Notificação – SINAN) and molecular epidemiology was performed by repetitive sequence-based polymerase chain reaction (rep-PCR; DiversiLab®, bioMerieux, France). Results The incidence of pertussis in the state of Paraná increased sharply from 0.15-0.76 per 100,000 habitants between 2007-2010 to 1.7-4.28 per 100,000 between 2011-2013. Patients with less than 1 year of age were more stricken (67.5%). Fifty-nine children (5%) developed pertussis even after receiving three doses and two diphtheria-tetanus-pertussis (DTP) boosters vaccine. The most common complications were pneumonia (14.5%), otitis (0.9%), and encephalopathy (0.7%). Isolates of B. pertussis were grouped into two groups (G1 and G2) and eight distinct patterns (G1: P1-P5 and G2: P6-P8). Conclusion The resurgence of pertussis should stimulate new research to develop vaccines with greater capacity of protection against current clones and also encourage implementation of new strategies for vaccination in order to reduce the risk of disease in infants.
Authors and Affiliations
Rosângela Torres
Keywords
Related Articles
- EP ID EP557039
- DOI 10.1016/j.jped.2014.09.004
- Views 70
- Downloads 0
Tongue development in stillborns autopsied at different gestational ages
Objectives This study aimed to analyze, through the morphometric method, the perimeter and length of the tongue, the collagen fibers, and the perimeter of blood vessels at different gestational ages and fetal weights. M...
Effectiveness of a measure program to prevent admission hypothermia in very low-birth weight preterm infants
Objective To evaluate the effectiveness of a thermoregulation bundle for preventing admission hypothermia in very low-birth weight preterm infants. Methods Interventional study with retrospective evaluation of data unde...
Critical assessment of the pH of children's soap
Objective To evaluate the pH value of children's antibacterial soaps and syndets used in children's baths and verify whether there is information regarding pH on the product label. Methods Quantitative, cross-sectional,...
Obese fathers lead to an altered metabolism and obesity in their children in adulthood: review of experimental and human studies
Objective To discuss the recent literature on paternal obesity, focusing on the possible mechanisms of transmission of the phenotypes from the father to the children. Sources A non-systematic review in the PubMed databa...
New insights into the fecal microbiota of children living in a slum: association with small bowel bacterial overgrowth
The study by Mello et al. from the group of Dr. Mauro Batista de Morais provides additional information on the impact of living in a slum on small bowel bacterial overgrowth (SIBO), as well as some nutritional and anthro...