Retrospective assessment of qualification criteriaand efficasy of azathioprine therapyfor ulcerative colitis in children - experience of single center
Journal Title: Pediatria Współczesna. Gastroenterologia, Hepatologia i Żywienie Dziecka - Year 2007, Vol 9, Issue 2
Abstract
Aim of study: The aim of this study was the assessment of qualifications and efficacy of azathioprine (AZA) treatment in children with ulcerative colitis (UC). Material and methods: 25 patients treated for UC with azathioprine were enrolled to the study (14 females and 11 males, aged from 1 to 17 years). Patients' data were retrospectively analyzed. In all cases azathioprine was administrated because of failed steroid and 5 aminosalicylic compounds therapy. 10 patients (40%) were previously treated with prednisone and sulfosalazine, 4 patients (16%) received pre-dnisone and mesalazine, 5 (20%) sulfasalazine alone. Steroids and aminosalicylates was resulted in neither clinical (n=25, 100%), nor en-doscopic(n=9, 35%) and histopathological (n=5, 20%) improvement. Azathioprine treatment was instituted in 8 children (32%) duringfirst exacerbation of UC. Remaining patients got this therapy for second or another exacerbation. Results: AZA therapy resulted in improvement of clinical, endoscopic and histopathological status in 20 patients (80%). Exacerbation of UC was observed in 7 cases (28%) before 6 months of AZA therapy. The azathioprine was weaned off in two patients (5%) because of thrombocythopenia and in one (2.5%) because of acute pancreatitis. 22 patients (88%) didn't present sideeffects of AZA. Cyclosporine therapy was started because of severe exacerbation of UC in 10 patients (40%), in 4 children (16%) in this group colectomy was performed. 7 patients (28%) have been still receiving AZA. Conclusions: In analyzed group AZA therapy was started because of steroid resistance and steroid dependence. AZA seems to be safe and well tolerated treatment of UC in children.
Authors and Affiliations
Jarosław Kierkuś, Michał Szczepański, Maciej Dądalski, Diana Kamińska, Magdalena Łukaszewska, Piotr Socha, Józef Ryżko, Jerzy Socha
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